Oxidative DNA damage is significantly correlated with flow-mediated dilation in patients with coronary artery disease
| Autor: | Ümit Türkoğlu, Ahmet Kaya Bilge, Selda Can Arkaya, Yilmaz Nisanci, Beste Ozben, Selen Yurdakul |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Brachial Artery DNA damage Disease Coronary Artery Disease Biology General Biochemistry Genetics and Molecular Biology Coronary artery disease chemistry.chemical_compound Internal medicine medicine.artery medicine Humans Endothelial dysfunction Brachial artery Aged Ultrasonography Cholesterol General Medicine Middle Aged medicine.disease Vasodilation Blood pressure chemistry DNA glycosylase Case-Control Studies Cardiology Female Comet Assay Endothelium Vascular Oxidation-Reduction DNA Damage |
| Zdroj: | Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 56(7) |
| ISSN: | 1081-5589 |
| Popis: | Background Oxidative DNA damage was increased in patients with coronary artery disease (CAD) and correlated with the severity of the disease. Endothelial dysfunction plays a major role in atherosclerotic process. The aim of this study was to explore a relation between oxidative DNA damage and endothelial function in patients with CAD. Methods Forty patients with CAD and 20 age- and sex-matched healthy controls were included. Endothelial function was assessed by brachial artery ultrasonography. The DNA damage was determined by comet method. Results The DNA damage scores after incubation with repair enzymes were found significantly higher in the patients with CAD ( P = 0.04). There was a significant negative correlation between oxidized DNA damage scores and flow-mediated dilation (FMD) measures in the patients with CAD ( r = −0.41; P = 0.009). Oxidized DNA damage scores were significantly and independently associated with FMD (standardized β = −0.455; P = 0.009) when adjusted by age, sex, smoking status, blood pressure, and cholesterol levels. Conclusions The DNA damage scores were significantly inversely correlated with FMD measures. To our knowledge, this is the first study showing the presence of a relation between DNA damage scores and FMD. |
| Databáze: | OpenAIRE |
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