Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport
| Autor: | Anthony W. Norman, James F. Myrtle |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Time Factors Metabolite chemistry.chemical_element Rickets Calcium chemistry.chemical_compound Oral administration Internal medicine polycyclic compounds medicine Vitamin D and neurology Cholecalciferol Calcium metabolism Multidisciplinary Chemistry Biological Transport medicine.disease Small intestine Intestines Endocrinology medicine.anatomical_structure lipids (amino acids peptides and proteins) |
| Zdroj: | Science. 171:79-82 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.171.3966.79 |
| Popis: | A major polar metabolite of cholecalciferol (vitamin D(3)) obtained from chick intestines is over four times as effective as cholecalciferol and over two times as effective as 25-hydroxycholecalciferol in stimulating intestinal calcium transport 24 hours after administration. Following a considerable lag, cholecalciferol and its 25-hydroxy derivative produce a maximum stimulation of the transport response at 24 to 48 hours. The polar intestinal metabolite greatly shortens this lag, stimulating maximum calcium transport by 9 hours. At 9 hours this metabolite is at least 13 times as active as the parent cholecalciferol and as such is a likely candidate for the biologically active form of cholecalciferol in the intestine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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