Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1-40: A Correlational Study in Healthy Adults
| Autor: | Josef Priller, Marion Ortner, Achim Berthele, Marie-Sophie Franz, Paul Theo Zebhauser, Timo Grimmer, Oliver Goldhardt, Janine Diehl-Schmid |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Amyloid β statistics & numerical data [Healthy Volunteers] Physiology Clinical settings Total tau tau Proteins cerebrospinal fluid [Amyloid beta-Peptides] 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid mental disorders Medicine Humans ddc:610 cerebrospinal fluid [Peptide Fragments] Amyloid beta-Peptides Models Statistical business.industry General Neuroscience Age Factors amyloid beta-protein (1-40) General Medicine Middle Aged amyloid-beta 1–40 total-Tau Healthy Volunteers Peptide Fragments Clinical Practice Psychiatry and Mental health Clinical Psychology 030104 developmental biology cerebrospinal fluid [Biomarkers] cerebrospinal fluid [tau Proteins] Correlational study Biomarker (medicine) Female Geriatrics and Gerontology business Alzheimer’s disease 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of Alzheimer's disease 83(1), 155-162 (2021). doi:10.3233/JAD-210286 |
| ISSN: | 1875-8908 |
| DOI: | 10.3233/JAD-210286 |
| Popis: | Background: Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship between age and total-Tau in the cerebrospinal fluid is yet to be fully understood. While past studies reported a correlation between age and total-Tau in the cerebrospinal fluid of healthy adults, in clinical practice the same cut-off value is used independently of patient’s age. Objective: To further explore the relationship between age and total-Tau and to disentangle neurodegenerative from drainage-dependent effects. Methods: We analyzed cerebrospinal fluid samples of 76 carefully selected cognitively healthy adults and included amyloid-β 1–40 as a potential marker of drainage from the brain’s interstitial system. Results: We found a significant correlation of total-Tau and age, which was no longer present when correcting total-Tau for amyloid-β 1–40 concentrations. These findings were replicated under varied inclusion criteria. Conclusion: Results call into question the association of age and total-Tau in the cerebrospinal fluid. Furthermore, they suggest diagnostic utility of amyloid-β 1–40 as a possible proxy for drainage-mechanisms into the cerebrospinal fluid when interpreting biomarker concentrations for neurodegenerative diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|