Reduced structural connectivity in Insomnia Disorder
| Autor: | Angus B. A. Stevner, Peter Vuust, Henrique M. Fernandes, Kira Vibe Jespersen, Eus J.W. Van Someren, Morten L. Kringelbach, Stine Derdau Sørensen |
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| Přispěvatelé: | Integrative Neurophysiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, APH - Mental Health, Netherlands Institute for Neuroscience (NIN) |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cognitive Neuroscience insomnia insula 03 medical and health sciences Behavioral Neuroscience Young Adult 0302 clinical medicine Text mining Neuroimaging SDG 3 - Good Health and Well-being Sleep Initiation and Maintenance Disorders Neural Pathways mental disorders Insomnia Humans Medicine structural connectivity sleep Psychiatry Aged Sleep disorder neuroimaging business.industry Perspective (graphical) General Medicine Middle Aged medicine.disease diffusion tensor imaging Sleep in non-human animals 030228 respiratory system Interoception Female medicine.symptom Psychology business Insula 030217 neurology & neurosurgery Clinical psychology Diffusion MRI |
| Zdroj: | Jespersen, K V, Stevner, A, Fernandes, H, Sørensen, S D, Van Someren, E, Kringelbach, M & Vuust, P 2020, ' Reduced structural connectivity in Insomnia Disorder ', Journal of Sleep Research, vol. 29, no. 1, e12901, pp. 1-10 . https://doi.org/10.1111/jsr.12901 Journal of Sleep Research, 29(1):e12901, 1-10. Wiley-Blackwell Journal of Sleep Research, 29(1):e12901. Wiley-Blackwell Journal of Sleep Research. Wiley-Blackwell Jespersen, K V, Stevner, A, Fernandes, H, Sørensen, S D, Van Someren, E, Kringelbach, M L & Vuust, P 2020, ' Reduced structural connectivity in Insomnia Disorder ', Journal of Sleep Research, vol. 29, no. 1, e12901 . https://doi.org/10.1111/jsr.12901 Jespersen, K V, Stevner, A, Fernandes, H, Sørensen, S D, Van Someren, E, Kringelbach, M & Vuust, P 2020, ' Reduced structural connectivity in Insomnia Disorder ', Journal of Sleep Research, vol. 29, no. 1, e12901 . https://doi.org/10.1111/jsr.12901 |
| ISSN: | 0962-1105 |
| DOI: | 10.1101/510784 |
| Popis: | Insomnia Disorder is the most prevalent sleep disorder and it involves both sleep difficulties and daytime complaints. The neural underpinnings of Insomnia Disorder are poorly understood. Existing neuroimaging studies are limited by their focus on local measures and specific regions of interests. To address this shortcoming, we applied a data-driven approach to assess differences in whole-brain structural connectivity between adults with Insomnia Disorder and matched controls without sleep complaints. We used diffusion tensor imaging and probabilistic tractography to assess whole-brain structural connectivity and examined group differences using Network-Based Statistics. The results revealed a significant difference in the structural connectivity of the two groups. Participants with Insomnia Disorder showed reduced connectivity in a subnetwork that was largely left lateralized, including mainly fronto-subcortical connections with the insula as a key region. By taking a whole-brain network perspective, our study succeeds at integrating previous inconsistent findings, and our results reveal that reduced structural connectivity of the left insula and the connections between frontal and subcortical regions are central neurobiological features of Insomnia Disorder. The importance of these areas for interoception, emotional processing, stress responses and the generation of slow wave sleep may help guide the development of neurobiology-based models of the highly prevalent condition of Insomnia Disorder. |
| Databáze: | OpenAIRE |
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