Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features
| Autor: | Manabu Kinoshita, Motohiko Maruno, Kouichi Wada, Tetsuo Hashiba, Naoya Hashimoto, Toshiki Yoshimine, Tsuyosi Suzuki, Yasunori Fujimoto, Naoki Kagawa, Shuichi Izumoto, Youichi Saitoh |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.medical_treatment Estrogen receptor Neurosurgical Procedures Craniopharyngioma Predictive Value of Tests Progesterone receptor Biomarkers Tumor Humans Medicine Pituitary Neoplasms Child Receptor Aged Radiotherapy biology business.industry Patient Selection Middle Aged Prognosis medicine.disease Immunohistochemistry Radiation therapy Ki-67 Antigen Receptors Estrogen Hormone receptor Child Preschool Ki-67 biology.protein Female Surgery Neurology (clinical) Neoplasm Recurrence Local Receptors Progesterone business |
| Zdroj: | Surgical Neurology. 63:520-525 |
| ISSN: | 0090-3019 |
| DOI: | 10.1016/j.surneu.2004.08.094 |
| Popis: | Background Although craniopharyngiomas have a histologically benign nature, their treatment can be difficult. The correlation among clinical, proliferative, and immunohistologic features of female sex hormone receptors was determined in craniopharyngiomas to analyze whether they influence the growth of the tumor. Methods The study subjects were 43 patients with previously untreated craniopharyngioma who underwent surgery at our department over the past 15 years. Serial tissue sections were immunostained with the antibodies against estrogen receptor (ER), progesterone receptor (PR), and Ki-67. Results The Ki-67 labeling index was significantly higher in patients with regrowth (7.8%) than without regrowth (3.9%). ER and PR were detected in 9 of 30 (30%) craniopharyngiomas, and the incidence of postoperative tumor regrowth was significantly higher in patients negative for ER and PR (29%) than in those positive for both receptors (11%). Conclusions A high Ki-67 labeling index suggests a high possibility of tumor regrowth, and the presence of ER and PR is suggestive of a high tissue differentiating potential. ER and PR assay may be useful for determining the indication for additional radiation therapy in craniopharyngioma patients treated by incomplete resection. |
| Databáze: | OpenAIRE |
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