BNP combined with echocardiographic parameters to predict the risk of cardioembolic stroke
| Autor: | Jin Wei, Xudong Pan, Meng Zhang, Aijun Ma, Yuan Wang, Qing Peng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Vascular risk Fibrinogen 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Natriuretic Peptide Brain medicine Humans Cardiac structure cardiovascular diseases Aged Embolic Stroke Cardioembolic stroke Creatinine Ejection fraction Cholesterol business.industry Atrial fibrillation General Medicine Middle Aged medicine.disease Neurology chemistry Echocardiography 030220 oncology & carcinogenesis cardiovascular system Cardiology Female Surgery Neurology (clinical) business Biomarkers hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Clinical Neuroscience. 88:213-218 |
| ISSN: | 0967-5868 |
| Popis: | Previous studies have found that BNP and some indicators of cardiac structure and function are closely associated with atrial fibrillation, so we aim to investigate the potential role of BNP and echocardiographic parameters to identify the acute ischemic stroke with atrial fibrillation patients who have high risks of cardioembolic stroke based on it.436 AIS patients were divided into an AF group and non-AF group on the basis of the electrocardiogram and Holter results. Then we compared vascular risk factors, laboratory test indicators, and echocardiographic parameters among different groups.AIS with AF group had significantly higher age, CHD, previous medication, creatinine, d-dimer, fibrinogen, CRP, BNP, LAD, LVDd, LVDs and lower cholesterol, triglyceride, LDL and ejection fraction than the non-AF group (P 0.05). Increased BNP, LAD, LVDd, LVDs and ejection fraction reduction were independent risk factors to predict cardioembolic stroke. BNP and LAD could be the two most effective indicators of the high risk of cardioembolic stroke. The area under the curve (AUC) of BNP and LAD were 0.791 [95%CI (0.743-0.838), p 0.001), 0.786 [95%CI (0.739-0.833), p 0.001]. The combined score we designed improved the prediction effect of single-indicator. The AUC of it was 0.822 with a sensitivity of 69.5% and specificity of 83.9%.There was an apparent positive correlation between BNP and LAD in AIS patients (r = 0.327, P 0.001).BNP combined with echocardiographic parameters has outstanding value to predict the risk of cardioembolic stroke, especially for BNP and LAD. |
| Databáze: | OpenAIRE |
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