Pro198Leu polymorphism of GPx-1 gene and activity of erythrocytic glutathione peroxidase and lipid peroxidation products
| Autor: | Kukharchuk Vv, A. I. Kaminnyi, Yu. A. Shuvalova, Alexey N Meshkov |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Male GPX1 Glutathione Peroxidase Erythrocytes Polymorphism Genetic Base Sequence Proline Glutathione peroxidase General Medicine GPX4 Molecular biology General Biochemistry Genetics and Molecular Biology Minor allele frequency Lipid peroxidation chemistry.chemical_compound chemistry Leucine Genotype Humans Lipid Peroxidation Allele Gene DNA Primers |
| Zdroj: | Bulletin of experimental biology and medicine. 149(6) |
| ISSN: | 1573-8221 |
| Popis: | We studied the relationship between the GPx-1 gene Pro198Leu polymorphism genotype and activity of free-radical processes. In patients with documented CHD, the content of lipoperoxides and MDA in LDL, activity of glutathione peroxidase in erythrocytes, and genotype of GPx-1 gene Pro198Leu polymorphism were determined. In carriers of the minor allele, activity of glutathione peroxidase in erythrocytes was lower by 17% than in wild allele homozygotes, while the content of lipoperoxides and MDA in LDL was higher by 74 and 27%, respectively. We concluded than free-radical oxidation processes are more pronounced in carriers of the minor allele of GPx-1 gene Pro198Leu polymorphism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink