Effects of Non-Nutritive Sweeteners on Energy Intake, Body Weight and Postprandial Glycemia in Healthy and with Altered Glycemic Response Rats
| Autor: | Rubén Córdova-Uscanga, Carlos Alfonso Tovilla-Zárate, Meztli Ramos-García, Jorge L. Ble-Castillo, Alma Delia Genis-Mendoza, Juan C. Díaz-Zagoya, Isela Esther Juárez-Rojop, Viridiana Olvera-Hernández, Carlos Alfonso Álvarez-González, Carlos García-Vázquez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Sucralose Health (social science) Acceptable daily intake Normal diet 030309 nutrition & dietetics media_common.quotation_subject 030209 endocrinology & metabolism TP1-1185 Plant Science Health Professions (miscellaneous) Microbiology Article aspartame 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stevia Internal medicine energy metabolism medicine Nutritive Sweeteners Glycemic media_common 0303 health sciences business.industry Chemical technology sucralose Appetite appetite Endocrinology Postprandial chemistry rebaudioside A medicine.symptom business Weight gain Food Science |
| Zdroj: | Foods Volume 10 Issue 5 Foods, Vol 10, Iss 958, p 958 (2021) |
| ISSN: | 2304-8158 |
| DOI: | 10.3390/foods10050958 |
| Popis: | The aim of this study was to evaluate the effects of non-nutritive sweeteners (NNS) consumption on energy intake, body weight and postprandial glycemia in healthy and with altered glycemic response rats. Animals on normal diet (ND) or high-fat diet (HFD) were divided to receive NNS (sucralose, aspartame, stevia, rebaudioside A) or nutritive sweeteners (glucose, sucrose) for 8 weeks. The NNS were administered at doses equivalent to the human acceptable daily intake (ADI). A test using rapidly digestible starch was performed before and after treatments to estimate glycemic response. No effects of NNS consumption were observed on energy intake or body weight. Sucrose provoked an increased fluid consumption, however, energy intake, and weight gain were not altered. In ND, no effects of NNS on glycemic response were observed. In HFD, the glycemic response was increased after sucralose and stevia when only the final tolerance test was considered, however, after including the baseline test, these results were no longer significant compared to glucose. These findings provide further evidence suggesting that at the recommended doses, NNS do not alter feeding behavior, body weight or glycemic tolerance in healthy and with altered glycemic rats. |
| Databáze: | OpenAIRE |
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