Long-term Pathologic Changes of α1-Acid Glycoprotein (orosomucoid) Glycoforms in Autoimmune Thyroid Disease
| Autor: | T. Zimmermann-Belsing, Hans Perrild, G. From, Ulla Feldt-Rasmussen, T.C. Bøg-Hansen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Thyroid Hormones
endocrine system medicine.medical_specialty endocrine system diseases Graves' disease Immunology Thyroid Gland Orosomucoid Trab Thyroid peroxidase Internal medicine medicine Humans Immunology and Allergy Autoimmune disease Triiodothyronine Haptoglobins biology business.industry Thyroid Thyroiditis Autoimmune Autoantibody Blood Proteins medicine.disease Graves Disease medicine.anatomical_structure Endocrinology biology.protein business |
| Zdroj: | Autoimmunity. 35:441-447 |
| ISSN: | 1607-842X 0891-6934 |
| DOI: | 10.1080/0891693021000038721 |
| Popis: | We measured alpha1-acid-glycoprotein (AGP) in patients with autoimmune thyroid disease to study a possible relationship between microheterogeneity of the naturally occurring glycoforms of AGP and autoimmune thyroid disease.In a group of 12 fasting thyrotoxic patients (11 females, mean age: 43 years) with newly diagnosed Graves' disease (subgroup 1), we measured serum concentrations of total AGP and its 3 glycoforms (micromol/l, crossed affinity immunoelectrophoresis with con A in the first dimension gel) as well as total thyroxine, total triiodothyronine, thyrotropine, thyroid peroxidase antibodies (anti-TPO), antibodies against the TSH receptor (TRAb, TRAK), at baseline and after 12 months of antithyroid drug therapy (ATD). For comparison, 4 subgroups of thyroid patients (patients with Graves' disease and thyroid associated ophthalmopathy (TAO) (subgroup 2, n = 10), radioiodine treated Graves' patients (subgroup 3, n = 7), Graves' patients without TAO (subgroup 4, n = 13), patients with Hashimoto's thyroiditis (subgroup 5, n = 8)) and 25 normal controls (17 females, mean age: 38 years) were studied.In subgroups of TRAb positive Graves patients' serum levels of glycoform 1, 2 or 3 increased significantly (p0.005) after 12 months of ATD as compared to both baseline of that person or normal controls. No significant changes were found in the TRAb negative Hashimoto subgroup.Patients with autoimmune Graves' disease changed their relationship to AGP, and thus a role of AGP and its 3 glycoforms is suggested in the pathogenesis of Graves' disease. |
| Databáze: | OpenAIRE |
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