Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis
| Autor: | R J Zamora, Diego J Manzella, A A Pérez de la Hoz, L Vicente, G. De Rosa, Andrea Pisarevsky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Internal medicine Anti-nuclear antibody catastrophic antiphospholipid syndrome pulmonary renal syndrome lcsh:Medicine Catastrophic antiphospholipid syndrome Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans multiple organ failure 030212 general & internal medicine Leukocytosis Catastrophic Illness lcsh:RC31-1245 030203 arthritis & rheumatology Lupus anticoagulant Scleroderma Systemic business.industry lcsh:R Acute kidney injury Glomerulonephritis Diffuse alveolar hemorrhage Middle Aged Antiphospholipid Syndrome medicine.disease Neutrophilia Systemic sclerosis medicine.symptom business |
| Zdroj: | Reumatismo, Vol 71, Iss 2 (2019) |
| ISSN: | 2240-2683 0048-7449 |
| Popis: | A 62-year-old man with a history of systemic sclerosis was admitted with diffuse alveolar hemorrhage and acute kidney injury without clinical data suggestive of glomerulonephritis. Laboratory tests showed anemia, leukocytosis with neutrophilia, thrombocytopenia, elevated serum creatinine and metabolic acidosis. Antinuclear antibodies were positive at a titer of 1/640 (speckled, 1/160; nucleolar, 1/320) while rheumatoid factor, anti Scl-70, anti-centromere, anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibodies were negative and serum complement levels were within normal range. During the following days, the patient developed multiple organ failure and, eventually, died. Lupus anticoagulant was revealed positive after the patient’s death, suggesting a catastrophic antiphospholipid syndrome. Clinical data and autopsy were consistent with this diagnosis. |
| Databáze: | OpenAIRE |
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