Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: Benefits of slow infusion
| Autor: | Péter Hamar, László Dézsi, András Szabó, Tamás Bakos, Gabor G. Kovacs, Gábor Szénási, Balázs Győrffy, Tamás Mészáros, Janos Szebeni, Miklós Garami, Erik Őrfi, Gergely Milosevits |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Antifungal Agents Time Factors Adverse drug effects Rat model Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology Pharmacology Drug Hypersensitivity 03 medical and health sciences Amphotericin B medicine Animals Humans General Materials Science Rats Wistar Child Infusions Intravenous Complement Activation 030304 developmental biology 0303 health sciences Adult patients Infusion time business.industry Slow infusion 021001 nanoscience & nanotechnology 3. Good health Rats Complement C3a Molecular Medicine 0210 nano-technology business medicine.drug |
| Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine |
| ISSN: | 1549-9634 |
| DOI: | 10.1016/j.nano.2021.102366 |
| Popis: | Intravenous administration of lipid-based nanodrugs can cause hypersensitivity, also known as infusion reactions (IRs), that can be attenuated by slow infusion in adult patients. We studied the role of infusion rate and complement (C) activation in IRs in pediatric patients treated with Abelcet, and also in anesthetized rats. IRs were observed in 6 out of 10 (60%) patients who received Abelcet infusion in 4 h or less, while no patients who received the infusion in 6 h showed C activation or IRs. The rat model indicated an inverse relationship between infusion speed and Abelcet-induced hypotension, taken as an experimental endpoint of IRs, while the rise of C3a in blood, an index of C activation, directly correlated with hypotension. The results suggest that pediatric patients are more prone to produce IRs, and that the optimal infusion time of Abelcet may be much longer than the presently recommended 2 h. |
| Databáze: | OpenAIRE |
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