Effect of sitagliptin on glucose control in type 2 diabetes mellitus after Roux-en-Y gastric bypass surgery
| Autor: | Sarah Stano, Kiarra Levesque, Betsy L. Rojas, Roxanne Dutia, Marlena M. Holter, James McGinty, Esmeralda Pierini, Michael Ahlers, Ankit Shah, Scott Belsley, Blandine Laferrère |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Gastric Bypass 030209 endocrinology & metabolism Type 2 diabetes Dipeptidyl peptidase-4 inhibitor 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Article Sitagliptin Phosphate 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Longitudinal Studies Aged Glycated Hemoglobin Gastric bypass surgery business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Combined Modality Therapy Postprandial Diabetes Mellitus Type 2 Sitagliptin Female business medicine.drug |
| Zdroj: | Diabetes, Obesity and Metabolism. 20:1018-1023 |
| ISSN: | 1462-8902 |
| DOI: | 10.1111/dom.13139 |
| Popis: | The present study was a 4-week randomized trial to assess the efficacy and safety of sitagliptin, a dipeptidyl-peptidase-4 inhibitor, in persistent or recurring type 2 diabetes after Roux-en-Y gastric bypass surgery (RYGB). Participants (n = 32) completed a mixed meal test (MMT) and self-monitoring of plasma glucose (SMPG) before and 4 weeks after randomization to either sitagliptin 100 mg daily or placebo daily. Questionnaires were administered to assess gastrointestinal discomfort. Outcome variables were glucose, active glucagon-like peptide-1 and β-cell function during the MMT, and glucose levels during SMPG. Age (56.3 ± 8.2 years), body mass index (34.4 ± 6.7 kg/m2 ), glycated haemoglobin (7.21 ± 0.77%), diabetes duration (12.9 ± 10.0 years), years since RYGB (5.6 ± 3.3 years) and β-cell function did not differ between the placebo and sitagliptin groups at pre-intervention. Sitagliptin was well tolerated, decreased postprandial glucose levels during the MMT (from 8.31 ± 1.92 mmol/L to 7.67 ± 1.59 mmol/L, P = 0.03) and mean SMPG levels, but had no effect on β-cell function. In patients with diabetes and mild hyperglycemia after RYGB, a short course of sitagliptin provided a small but significant glucose-lowering effect, with no identified improvement in β-cell function. |
| Databáze: | OpenAIRE |
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