Oxytocin in the periaqueductal grey regulates nociception in the rat
| Autor: | Jin-Ying Liang, Jing Zhang, Pei-Yong Qiu, Peng Li, Xiao-Yi Zhang, Jun Yang, Xi-Qin Yan, Da-Xin Wang, Fu-Lin Yan, Yan-Juan Pan, Fang Hao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Pain Threshold medicine.medical_specialty Microinjections Physiology medicine.drug_class Clinical Biochemistry Central nervous system Pain Ornipressin Periaqueductal grey Stimulation Oxytocin Biochemistry Rats Sprague-Dawley Cellular and Molecular Neuroscience Endocrinology Internal medicine Threshold of pain medicine Animals Periaqueductal Gray Receptor Pain Measurement Chemistry Receptor antagonist Rats Nociception medicine.anatomical_structure nervous system Receptors Oxytocin hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Regulatory Peptides. 169:39-42 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2011.04.007 |
| Popis: | Studies have demonstrated that oxytocin (OXT) plays important roles in pain modulation in the central nervous system, and there are OXT receptors in the periaqueductal grey (PAG). The experiment was designed to investigate the effect of OXT in the PAG on antinociception. The results showed that (1) intra-PAG injection of OXT increased the pain threshold, whereas the local administration of the high specific OXT receptor antagonist, desGly-NH(2), d(CH(2))(5)[D-Tyr(2), Thr-sup-4]OVT decreased the pain threshold in a dose-dependent manner; (2) Pain stimulation could elevate OXT concentration in the PAG perfusion liquid. The data suggested that OXT in the PAG was involved in the antinociceptive process through the OXT receptor. |
| Databáze: | OpenAIRE |
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