Sternal Resection for Breast Cancer Metastases
| Autor: | Henrik Menke, Stefan Sponholz, Natalie Baldes, Joachim Schirren, Selma Oguzhan, Moritz Schirren |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult medicine.medical_specialty Sternum Lung Neoplasms Time Factors Databases Factual medicine.medical_treatment Breast Neoplasms Kaplan-Meier Estimate 030204 cardiovascular system & hematology Disease-Free Survival Surgical Flaps Resection 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors medicine Humans Neoplasm Invasiveness Pneumonectomy Survival analysis Mastectomy Aged Retrospective Studies Lung business.industry Soft tissue Retrospective cohort study Middle Aged medicine.disease Sternotomy Confidence interval Surgery medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Thoracic and cardiovascular surgeon. 66(2) |
| ISSN: | 1439-1902 |
| Popis: | Background Sternal infiltration of breast cancer (BC) is a rare but known phenomenon. Sternal resection for this cancer is not completely investigated. For this reason, the aim of this study was to examine long-term survival and prognosticators for prolonged survival of our patients after sternal resection. Also, morbidity and mortality were investigated. Materials and Methods We retrospectively analyzed our prospective database of 20 patients who underwent a sternum resection (partial/complete) for BC in our institution between 2003 and 2014. Furthermore, patients with additional lung metastases were included. All patients received a mesh-methyl methacrylate technique (“sandwich technique”) and soft tissue coverage with myocutaneous muscle flap. Long-term outcomes and survival curves were performed by the Kaplan–Meier method. Survival differences and prognosticators were investigated using the log-rank test. Results Median survival was 32 months (95% confidence interval, 8–56 months). One-, 3-, and 5-year overall survivals were 79, 39, and 39%. There was a low morbidity and mortality with 35% (minor complications 30% and major complications 5%) and 0%. As prognosticators for longer survival, a positive hormone status (estrogen or progesterone) (p = 0.070) showed a trend. Neither age, primary mastectomy, disease-free interval Conclusion Sternal resections for BC patients can be associated with promising long-term survival. R0 resection, good functional and cosmetic results are achievable with low morbidity and mortality. Patients with additional lung metastases should not be routinely excluded from resection and should be discussed in interdisciplinary tumor boards. |
| Databáze: | OpenAIRE |
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