Patterned cortical tension mediated by N-cadherin controls cell geometric order in the Drosophila eye
| Autor: | Pruthvi Chavadimane Shivakumar, Edith Laugier, Eunice HoYee Chan, Pierre-François Lenne, Raphaël Clément |
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| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Matière et Systèmes Complexes (MSC) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
QH301-705.5 Science Cell Morphogenesis morphogenesis [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology General Biochemistry Genetics and Molecular Biology Contractility modelling 03 medical and health sciences developmental biology cell mechanics stem cells cell biology medicine cell contractility Biology (General) Cell adhesion [SDV.BDD]Life Sciences [q-bio]/Development Biology Tissue homeostasis General Immunology and Microbiology D. melanogaster Cell adhesion molecule Cadherin General Neuroscience cell adhesion General Medicine Adhesion cell shapes Cell biology 030104 developmental biology medicine.anatomical_structure Medicine |
| Zdroj: | eLife eLife, eLife Sciences Publication, 2017, 6, ⟨10.7554/eLife.22796⟩ eLife, Vol 6 (2017) eLife, 2017, 6, ⟨10.7554/eLife.22796⟩ |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.22796⟩ |
| Popis: | International audience; Adhesion molecules hold cells together but also couple cell membranes to a contractile actomyosin network, which limits the expansion of cell contacts. Despite their fundamental role in tissue morphogenesis and tissue homeostasis, how adhesion molecules control cell shapes and cell patterns in tissues remains unclear. Here we address this question in vivo using the Drosophila eye. We show that cone cell shapes depend little on adhesion bonds and mostly on contractile forces. However, N-cadherin has an indirect control on cell shape. At homotypic contacts, junctional N-cadherin bonds downregulate Myosin-II contractility. At heterotypic contacts with E-cadherin, unbound N-cadherin induces an asymmetric accumulation of Myosin-II, which leads to a highly contractile cell interface. Such differential regulation of contractility is essential for morphogenesis as loss of N-cadherin disrupts cell rearrangements. Our results establish a quantitative link between adhesion and contractility and reveal an unprecedented role of N-cadherin on cell shapes and cell arrangements. |
| Databáze: | OpenAIRE |
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