Long-term familial Mediterranean fever remission on successful hepatitis C virus treatment in a patient not responding to colchicine: a case report
| Autor: | Susanna Ananyan, Manik Gemilyan, Gagik Hakobyan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Cirrhosis Hepatitis C virus Familial Mediterranean fever lcsh:Medicine Case Report medicine.disease_cause Chronic hepatitis C Antiviral Agents Inflammasome Autoinflammatory disorders Helicobacter Infections Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Ribavirin Medicine Humans 030203 arthritis & rheumatology Hepatitis business.industry lcsh:R Interferon-alpha General Medicine Hepatitis C Hepatitis C Chronic medicine.disease Recombinant Proteins Tubulin Modulators Colchicine resistance 030104 developmental biology chemistry Hepatocellular carcinoma Interferon Drug Therapy Combination Female business Colchicine Serositis |
| Zdroj: | Journal of Medical Case Reports Journal of Medical Case Reports, Vol 12, Iss 1, Pp 1-5 (2018) |
| ISSN: | 1752-1947 |
| Popis: | Background Familial Mediterranean fever is an autosomal recessive disorder characterized by periodic febrile attacks of aseptic serositis and/or arthritis. The main treatment is colchicine which prevents attacks in the majority of patients except for a group of colchicine-resistant cases. Chronic hepatitis C is a viral infection causing chronic inflammation of liver tissue (hepatitis) which ultimately progresses to fibrosis and liver cirrhosis with a high chance of hepatocellular carcinoma. However, we found no data in the literature concerning the impact of hepatitis C on the course of attacks of familial Mediterranean fever. Case presentation We report a case of a 21-year-old white woman with familial Mediterranean fever who had not been responding to a high dose of colchicine (2 mg/day). She presented to our clinic with a finding of chronic hepatitis C genotype 3 infection. After successful antiviral therapy with peginterferon and ribavirin, she became attack-free for 2 years and went on to a lower dose of colchicine. Conclusions This unusual case illustrates complete resolution of attacks of autoinflammatory disease after drug-induced clearance of chronic hepatitis C infection. Coexisting infections should be viewed as potentially altering the course of autoinflammatory disorders, and any attempt to cure the infections should be made in order to gain an added value of benefiting the chronic disease. This case highlights the interrelation of external pathogen-related and genetically inherited alterations in immunity and the importance of considering the whole spectrum of possible causative factors rather than implementing separate guidelines in order to achieve best quality of medical care in any given patient. |
| Databáze: | OpenAIRE |
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