An iterative sparse deconvolution method for simultaneous multicolor 19 F‐MRI of multiple contrast agents

Autor: Mariah R R Daal, Zahi A. Fayad, Rob C. I. Wüst, Alexander Maier, Claudia Calcagno, Gustav J. Strijkers, Sonum Naidu, Willem J. M. Mulder, Bram F. Coolen, Jasper Schoormans, Abraham J. P. Teunissen, Aart J. Nederveen, Brenda L. Sanchez-Gaytan, Christopher Faries
Přispěvatelé: AMS - Ageing and Morbidity, Precision Medicine, ICMS Core, Graduate School, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, AMS - Restoration & Development, AMS - Sports & Work, ANS - Brain Imaging, Laboratory Genetic Metabolic Diseases, ACS - Heart failure & arrhythmias, AMS - Ageing & Morbidty, Radiology and Nuclear Medicine, CCA - Imaging and biomarkers, Medical Biochemistry, Biomedical Engineering and Physics
Rok vydání: 2019
Předmět:
Male
Scanner
SDG 16 - Peace
Materials science
Full Papers—Preclinical and Clinical Imaging
Contrast Media
deconvolution
Injections
Intramuscular
Imaging phantom
Spectral line
030218 nuclear medicine & medical imaging
Fluorine-19 Magnetic Resonance Imaging
19F
Mice
03 medical and health sciences
0302 clinical medicine
sparse MRI
Robustness (computer science)
Crown Ethers
Image Processing
Computer-Assisted
Animals
Computer Simulation
Radiology
Nuclear Medicine and imaging
compressed sensing
Intravascular injection
fluorine MRI
Fluorocarbons
Full Paper
Phantoms
Imaging
SDG 16 - Peace
Justice and Strong Institutions
Fluorine
F-19
Justice and Strong Institutions
Hydrocarbons
Brominated
multiplex
Compressed sensing
Liver
Cell Tracking
Nanoparticles
Deconvolution
Artifacts
Biological system
Algorithms
Spleen
multicolor
030217 neurology & neurosurgery
Preclinical imaging
Zdroj: Magnetic Resonance in Medicine, 83(1), 228-239. John Wiley and Sons Inc.
Magnetic Resonance in Medicine, 83(1), 228-239. Wiley
Magnetic Resonance in Medicine
Magnetic resonance in medicine, 83(1), 228-239. John Wiley and Sons Inc.
Schoormans, J, Calcagno, C, Daal, M R R, Wüst, R C I, Faries, C, Maier, A, Teunissen, A J P, Naidu, S, Sanchez-Gaytan, B L, Nederveen, A J, Fayad, Z A, Mulder, W J M, Coolen, B F & Strijkers, G J 2020, ' An iterative sparse deconvolution method for simultaneous multicolor 19 F-MRI of multiple contrast agents ', Magnetic Resonance in Medicine, vol. 83, no. 1, pp. 228-239 . https://doi.org/10.1002/mrm.27926
ISSN: 1522-2594
0740-3194
DOI: 10.1002/mrm.27926
Popis: Purpose: 19F-MRI is gaining widespread interest for cell tracking and quantification of immune and inflammatory cells in vivo. Different fluorinated compounds can be discriminated based on their characteristic MR spectra, allowing in vivo imaging of multiple 19F compounds simultaneously, so-called multicolor 19F-MRI. We introduce a method for multicolor 19F-MRI using an iterative sparse deconvolution method to separate different 19F compounds and remove chemical shift artifacts arising from multiple resonances. Methods: The method employs cycling of the readout gradient direction to alternate the spatial orientation of the off-resonance chemical shift artifacts, which are subsequently removed by iterative sparse deconvolution. Noise robustness and separation was investigated by numerical simulations. Mixtures of fluorinated oils (PFCE and PFOB) were measured on a 7T MR scanner to identify the relation between 19F signal intensity and compound concentration. The method was validated in a mouse model after intramuscular injection of fluorine probes, as well as after intravascular injection. Results: Numerical simulations show efficient separation of 19F compounds, even at low signal-to-noise ratio. Reliable chemical shift artifact removal and separation of PFCE and PFOB signals was achieved in phantoms and in vivo. Signal intensities correlated excellently to the relative 19F compound concentrations (r−2 = 0.966/0.990 for PFOB/PFCE). Conclusions: The method requires minimal sequence adaptation and is therefore easily implemented on different MRI systems. Simulations, phantom experiments, and in-vivo measurements in mice showed effective separation and removal of chemical shift artifacts below noise level. We foresee applicability for simultaneous in-vivo imaging of 19F-containing fluorine probes or for detection of 19F-labeled cell populations.
Databáze: OpenAIRE
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