Prostate-Specific Antigen Density and Gleason Score Predict Adverse Pathologic Features in Patients with Clinically Localized Prostate Cancer
| Autor: | Simin Arfae, Seyed Ali Momeni, Elnaz Ayati, Afshin Mortazavi, M. Taherimahmoudi, Mohammad Reza Nowroozi, Solmaz Ohadian Moghadam, Hassan Jamshidian, Mohsen Ayati |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Urology medicine.medical_treatment 030232 urology & nephrology urologic and male genital diseases 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate PSA Density Prostate Neoplasm Medicine Stage (cooking) PSA Velocity business.industry Prostatectomy Brief Report Adverse Pathologic Feature Cancer medicine.disease Prostate-specific antigen medicine.anatomical_structure 030220 oncology & carcinogenesis Prostate neoplasm business |
| Zdroj: | Nephro-urology Monthly |
| ISSN: | 2251-7014 2251-7006 |
| Popis: | Background According to recent studies, prostate cancer is the second most common cancer among Iranian men. Radical prostatectomy has been considered the gold standard treatment in patients with clinically localized prostate cancer. Gleason score, PSA density, and PSA velocity are some of the parameters used to predict adverse pathologic features. Objectives The aim of this study was to evaluate the prognostic value of PSA density and Gleason score in predicting adverse pathologic features in patients with localized prostate cancer who undergo radical prostatectomy. Methods We conducted a cross-sectional study of 105 patients with localized prostate cancer who underwent radical prostatectomy between 2006 and 2013. We recorded Gleason scores and PSA levels, in addition to the results of pathological evaluations after radical prostatectomy, including prostate volume, stage, LNI (lymph node involvement), SVI (seminal vesicle invasion), and extraprostatic extension (EPE). Data were analyzed using SPSS version 21. Results Mean PSA density was 0.27 (0.17 SD). The frequencies of EPE, SVI, and LNI were 21.9, 16.2, and 2.9, respectively. The Mann-Whitney U-test demonstrated a significant correlation between PSA density and adverse pathologic features (EPE, SVI, and LNI). Conclusions PSA, PSA density, and Gleason score should be considered together in order to more accurately predict the adverse pathologic features of prostate cancer. |
| Databáze: | OpenAIRE |
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