Diagnostic accuracy of myocardial perfusion imaging in a study population without post-test referral bias
| Autor: | Henrik Boel Jørgensen, Annegrete Veje, Henrik Wulff Christensen, Werner Vach, Allan Johansen, Torben Haghfelt, Poul Flemming Høilund-Carlsen |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Referral Denmark Myocardial Ischemia Comorbidity Coronary Artery Disease Coronary stenosis Coronary Angiography Risk Assessment Sensitivity and Specificity Myocardial perfusion imaging Bias Risk Factors Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective cohort study Referral and Consultation Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Incidence Reproducibility of Results Middle Aged Prognosis medicine.disease Angiography Cardiology Population study Female Radiology Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Johansen, A, Høilund-Carlsen, P F, Christensen, H W, Vach, W, Boel-Jørgensen, H, Veje, A & Haghfelt, T 2005, ' Diagnostic accuracy of myocardial perfusion imaging in a study population without post-test referral bias ', Journal of Nuclear Cardiology, vol. 12, no. 5, pp. 530-537 . https://doi.org/10.1016/j.nuclcard.2005.04.012 |
| ISSN: | 1071-3581 |
| DOI: | 10.1016/j.nuclcard.2005.04.012 |
| Popis: | Most previous studies on the accuracy of myocardial perfusion imaging (MPI) are hampered by post-test referral bias, in that referral for coronary angiography was influenced by the MPI result. In this way, patients with a normal MPI result less frequently underwent catheterization, a tendency supposed to cause an underestimation of test specificity and an overestimation of test sensitivity. MPI by use of a gated dual-isotope protocol was undertaken before angiography in 357 patients referred for angiography for suspected stable angina pectoris. The MPI reports were kept secret to prevent post-test referral bias. The MPI study was normal in 215 patients (60%) and showed reversible perfusion abnormalities in 118 (33%) and fixed defects in 24 (7%). Angiography was normal in 231 patients (65%) and revealed 1 or more significant stenoses in 126 (35%). With angiography as the reference, the sensitivity and specificity of MPI for detecting significant coronary artery stenosis were 75% and 79%, respectively. In this prospective study without post-test referral bias, we found a lower sensitivity and slightly higher specificity than in studies with post-test referral bias. The imperfect accuracy may reflect differences between anatomic and physiologic imaging. (J Nucl Cardiol 2005;12:530-7.) |
| Databáze: | OpenAIRE |
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