Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy
| Autor: | Korhan Kahraman, Bahar Yetkin-Arik, Arjan W. Griffioen, Ingeborg Klaassen, Charlotte H.J.R. Jansen, Christianne A. R. Lok, Arnoud W. Kastelein, Miloš Vittori, Cornelis J.F. Van Noorden, Frédéric Amant, Aydan Biri, Reinier O. Schlingemann, Yani P. Latul |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Bevacizumab Angiogenesis Genital Neoplasms Female Endothelial cells Angiogenesis Inhibitors 03 medical and health sciences 0302 clinical medicine Internal medicine Genetics Tumor Microenvironment Medicine Humans In patient Tumor microenvironment Vascular disrupting agents Neovascularization Pathologic business.industry Anti-angiogenic therapy Cancer medicine.disease Gynecological cancer 030104 developmental biology Clinical research Anti angiogenesis 030220 oncology & carcinogenesis Non-tip cells Tip cells Female Immunotherapy business Endothelial cell metabolism medicine.drug |
| Zdroj: | Biochimica et biophysica acta. Reviews on cancer. 1875(1) |
| ISSN: | 1879-2561 |
| Popis: | Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment. ispartof: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER vol:1875 issue:1 ispartof: location:Netherlands status: published |
| Databáze: | OpenAIRE |
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