Enhancement of the localization and quantitative performance of fluorescence molecular tomography by using linear nBorn method
| Autor: | Xiaoquan Yang, Qingming Luo, Wenhao Xie, Yong Deng, Guoqiang Xu, Zhihong Zhang, Lichao Lian |
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| Rok vydání: | 2018 |
| Předmět: |
Astrophysics::High Energy Astrophysical Phenomena
Iterative reconstruction 01 natural sciences Projection (linear algebra) Imaging phantom Fluorescence 030218 nuclear medicine & medical imaging 010309 optics 03 medical and health sciences Mice 0302 clinical medicine Optics 0103 physical sciences Image Processing Computer-Assisted Animals Computer Simulation Tomography Physics business.industry Phantoms Imaging Detector Atomic and Molecular Physics and Optics Diffuse optical imaging Nonlinear system business Excitation Algorithms |
| Zdroj: | Optics express. 25(3) |
| ISSN: | 1094-4087 |
| Popis: | The nonlinear normalized Born ratio (nBorn) method normalizes emission data with excitation data nonlinearly, which makes the relative distributions of the normalized measurements different from those of the emission data. When compared with the reconstruction using only emission data, what the nonlinear nBorn method does is equivalent to introducing the noisy excitation data to emission data. In our linear nBorn method, the emission data for each projection is linearly normalized with the average excitation data of all detectors. Phantom and in vivo mice studies indicate that the linear nBorn method provides better localization and quantitative performance than the nonlinear nBorn method. |
| Databáze: | OpenAIRE |
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