MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study
| Autor: | Yi-Qing Jiang, Wei-Jun Hong, Hong Ni, Wei-Ling Li, Wan-fen Wang, Hai-Bin Zheng, Li-Na Wu, Feng Zhu, Xian-Wei Wang, Sha Luo |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Fibrinogen medicine.disease_cause Gastroenterology Polymorphism Single Nucleotide Risk Assessment Gene Frequency Matrix Metalloproteinase 10 Polymorphism (computer science) Risk Factors Internal medicine Genotype Medicine Humans Genetic Predisposition to Disease Risk factor Allele Genetic Association Studies Aged Aged 80 and over Rupture Spontaneous business.industry Cerebral infarction Rehabilitation Case-control study Middle Aged medicine.disease Prognosis Vulnerable plaque Plaque Atherosclerotic Phenotype Case-Control Studies Surgery Female Neurology (clinical) Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 30(10) |
| ISSN: | 1532-8511 |
| Popis: | Background Matrix metalloproteinase 10 (MMP-10) has a close relationship with carotid atherosclerosis (CAS) and cerebral infarction. The MMP-10 rs17435959 polymorphism causes a leucine to valine transition at codon 4 in exon 1 of the MMP-10 gene and may have functional effects. Objectives To investigate the relationship between the MMP-10 rs17435959 polymorphism and the formation and stability of CAS plaques. Materials and Methods The present case-control study contains 738 visitors who came to our health examination center for the first time. According to the carotid ultrasound examinations, visitors were classified into the vulnerable plaque group (41–86 years old, 141 male, 105 female), the stable plaque group (41–86 years old, 141 male, 105 female) and the no plaque group (41–85 years old, 141 male, 105 female). All visitors in the three groups were sex- and- age-matched, and cardiovascular and cerebrovascular diseases were absent. The polymorphism was genotyped by real-time polymerase chain reaction- restriction. Results Compared to the GG genotype, the frequency of the CC and CG genotypes was significantly more common in the vulnerable plaque group than in the no plaque group (18.7% vs. 7.7%, unadjusted P = 0.002). Moreover, compared to the G allele, the frequency of the C allele was significantly more common in the vulnerable plaque group than in the no plaque group (10.4% vs. 3.9%, unadjusted P = 0.000) and in the vulnerable plaque group than in the stable plaque group (10.4% vs. 5.1%, unadjusted P = 0.008). Binary logistic regression showed that the CC and CG genotype was independent risk factor for the formation (P = 0.019, OR = 1.961, 95% CI [1.117, 3.444]) and vulnerability (P = 0.035, OR = 1.842, 95% CI [1.045, 3.247]) of CAS plaques. Moreover, individuals who have the C allele showed a higher level of fibrinogen, which was an independent risk factor for the formation of CAS plaques (P = 0.000, OR = 2.425, 95% CI [1.475, 3.985]). Conclusions The rs17435959 polymorphism was associated with the formation and vulnerability of CAS plaques. Individuals who had variant-type MMP-10 showed higher levels of fibrinogen, which promoted the formation of CAS plaques. |
| Databáze: | OpenAIRE |
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