Characterization of the anti-α-Gal antibody profile in association with Guillain-Barré syndrome, implications for tick-related allergic reactions

Autor: Margarita Villar, Alejandro Cabezas-Cruz, Marinela Contreras, Francisco Feo Brito, Iván Pacheco, Elisa Gómez Torrijos, Isabel G. Fernández de Mera, José de la Fuente, Ernesto Doncel-Pérez, Christian Gortázar, José Francisco Lima-Barbero
Přispěvatelé: Instituto de Investigación en Recursos Cinegéticos (IREC), General University Hospital of Ciudad Real, Partenaires INRAE, University of Castilla-La Mancha (UCLM), Interlab-UMU, Interdisciplinary Laboratory of Clinical Analysis, Universidad de Murcia, Hospital Nacional de Parapléjicos de Toledo, Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire d'Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Veterinary Pathobiology, Center of Veterinary Health Sciences, Oklahoma State University [Stillwater], Supported by the Consejería de Educaci ́on, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY/17/180501/ 000185). Supported by the University of Castilla La Mancha (UCLM, Spain) and the Fondo Europeo de Desarrollo Regional, FEDER, EU. Supported by the UCLM. and funded by the Ministerio de Ciencia, Innovaci ́on y Universidades, Spain (grant FJC-2018-038277- I)., Junta de Comunidades de Castilla-La Mancha, European Commission, Universidad de Castilla La Mancha, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Allergy
Disease
Alpha-Gal
Adaptive Immunity
Immunoglobulin E
0302 clinical medicine
chemistry.chemical_classification
Aged
80 and over
Guillain-Barre syndrome
Middle Aged
Guillain-Barré syndrome
3. Good health
Infectious Diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Antibody
Food Hypersensitivity
Tick
Adult
Adolescent
030231 tropical medicine
Immunology
Biology
Guillain-Barre Syndrome
Microbiology
03 medical and health sciences
Young Adult
Immune system
parasitic diseases
medicine
Hypersensitivity
Humans
Alpha-Gal syndrome
Aged
Tick Bites
biology.organism_classification
medicine.disease
030104 developmental biology
chemistry
Immunoglobulin M
Insect Science
Immunoglobulin G
biology.protein
Parasitology
Glycoprotein
Zdroj: Ticks and Tick-Borne Diseases
Ticks and Tick-Borne Diseases, 2021, 12 (3), pp.1-6. ⟨10.1016/j.ttbdis.2021.101651⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 1877-959X
DOI: 10.1016/j.ttbdis.2021.101651⟩
Popis: Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the capacity to develop a protective response mediated by anti-α-Gal IgM/IgG antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop the alpha-Gal syndrome (AGS), a recently diagnosed disease mainly associated with allergic reactions to mammalian meat consumption. The etiology of the AGS is the exposure to tick bites and the IgE antibody response against α-Gal-containing glycoproteins and glycolipids. The objective of this study was to characterize the anti-α-Gal antibody response in association with the immune-mediated peripheral neuropathy, Guillain-Barré syndrome (GBS), and compare it with different factors known to modulate the antibody response to α-Gal such as exposure to tick bites and development of allergic reactions in response to tick bites. The results showed a significant decrease in the IgM/IgG response to α-Gal in GBS patients when compared to healthy individuals. In contrast, the IgM/IgG levels to α-Gal did not change in patients with allergic reactions to tick bites. The IgE response was not affected in GBS patients, but as expected, the IgE levels significantly increased in individuals exposed to tick bites and patients with tick-associated allergies. These results suggest that the immune pathways of anti-α-Gal IgM/IgG and IgE production are independent. Further studies should consider the susceptibility to allergic reactions to tick bites in GBS patients.
This work was supported by the Consejería de Educación, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY/17/180501/000185). MV was supported by the University of Castilla La Mancha (UCLM, Spain) and the Fondo Europeo de Desarrollo Regional, FEDER, EU. IGFM was supported by the UCLM. MC was funded by the Ministerio de Ciencia, Innovación y Universidades, Spain (grant FJC-2018-038277-I).
Databáze: OpenAIRE
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