Conjugative type IV secretion systems in Gram-positive bacteria

Autor: Nikolaus Goessweiner-Mohr, Elisabeth Grohmann, Karsten Arends, Walter Keller
Rok vydání: 2013
Předmět:
T4SS
type IV secretion system
Gene Transfer
Horizontal
Antibiotic resistance
Streptomycetaceae
DNA
Single-Stranded
Virulence
Review
Plasmid
Bacterial cell structure
TMH
trans-membrane helix
Type IV secretion
03 medical and health sciences
chemistry.chemical_compound
Bacterial Proteins
Cell Wall
Operon
Conjugative transfer
Enterococcus faecalis
Secretion
G+
Gram-positive
aa
amino acid(s)
Bacterial Secretion Systems
Molecular Biology
030304 developmental biology
Clostridium
Genetics
G−
Gram-negative
0303 health sciences
biology
030306 microbiology
Bacterial conjugation
Biological Transport
DNA
Gene Expression Regulation
Bacterial
T4S
type IV secretion
PG
peptidoglycan
biology.organism_classification
chemistry
Conjugation
Genetic
TMD
trans-membrane domain
Mobile genetic elements
ss
single stranded
Enterococcus
Bacteria
ds
double stranded
Plasmids
Zdroj: Plasmid
ISSN: 0147-619X
DOI: 10.1016/j.plasmid.2013.09.005
Popis: Highlights • The conjugative transfer mechanism of broad-host-range, Enterococcus sex pheromone and Clostridium plasmids is reviewed. • Comparisons with Gram-negative type IV secretion systems are presented. • The current understanding of the unique Streptomyces double stranded DNA transfer mechanism is reviewed.
Bacterial conjugation presents the most important means to spread antibiotic resistance and virulence factors among closely and distantly related bacteria. Conjugative plasmids are the mobile genetic elements mainly responsible for this task. All the genetic information required for the horizontal transmission is encoded on the conjugative plasmids themselves. Two distinct concepts for horizontal plasmid transfer in Gram-positive bacteria exist, the most prominent one transports single stranded plasmid DNA via a multi-protein complex, termed type IV secretion system, across the Gram-positive cell envelope. Type IV secretion systems have been found in virtually all unicellular Gram-positive bacteria, whereas multicellular Streptomycetes seem to have developed a specialized system more closely related to the machinery involved in bacterial cell division and sporulation, which transports double stranded DNA from donor to recipient cells. This review intends to summarize the state of the art of prototype systems belonging to the two distinct concepts; it focuses on protein key players identified so far and gives future directions for research in this emerging field of promiscuous interbacterial transport.
Databáze: OpenAIRE
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