Antibody levels after BNT162b2 vaccine booster and SARS-CoV-2 Omicron infection
| Autor: | Vietri, Maria Teresa, D'Elia, Giovanna, Caliendo, Gemma, Passariello, Luana, Albanese, Luisa, Maria Molinari, Anna, Francesco Angelillo, Italo |
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| Přispěvatelé: | Vietri, Maria Teresa, D'Elia, Giovanna, Caliendo, Gemma, Passariello, Luana, Albanese, Luisa, Maria Molinari, Anna, Francesco Angelillo, Italo |
| Rok vydání: | 2022 |
| Předmět: |
General Veterinary
General Immunology and Microbiology SARS-CoV-2 Health Personnel Public Health Environmental and Occupational Health COVID-19 Omicron variant Hepatitis B Vaccine Antibodies Viral Infectious Diseases Immunisation safety Neutralizing antibodie Humans Molecular Medicine Hepatitis B Vaccines Humoral immune response Booster vaccination BNT162 Vaccine Human |
| Zdroj: | Vaccine. 40:5726-5731 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2022.08.045 |
| Popis: | In the present study, immunogenicity data in 61 vaccinated healthcare workers (HCWs) either infection naïve (naïve HCWs) or with infection of Delta and/or Omicron COVID-19 (experienced HCWs) were evaluated up to 270days after the second dose of BNT162b2 vaccine and up to 90days after a booster dose. A decrease in antibody levels at 270days following administration of the second dose (p=0.0335) was observed, although values did not fall below the positivity threshold (33.8 BAU/ml). After booster vaccination, antibody levels increased after 30days (p=0.0486), with much higher values than after first and second vaccination. Antibody levels then decreased at 60 and 90days after the booster dose. A comparison between mean antibody levels of naïve and experienced HCWs revealed higher values in experienced HCWs, resulting from both natural and vaccination-induced immunity. A total of 14.7% of HCWs contracted the Omicron virus variant after the vaccine booster, although none showed severe symptoms. These results support that a booster dose results in a marked increase in antibody response that subsequently decreases over time. |
| Databáze: | OpenAIRE |
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