Copper Deficiency and Persistence of the Ductus arteriosus
| Autor: | Villa Elízaga I, Alliende Gonzales F, Antillón Klüssmann F |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Heart Defects
Congenital Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Offspring Iron Physiology Persistence (computer science) Rats Sprague-Dawley Pregnancy Internal medicine Ductus arteriosus medicine Animals Tissue Distribution Pharmacology (medical) cardiovascular diseases General Pharmacology Toxicology and Pharmaceutics Ductus Arteriosus Patent Experimental model business.industry Body Weight Ductus Arteriosus medicine.disease Pathophysiology Rats Pregnancy Complications Cholesterol Endocrinology medicine.anatomical_structure Animals Newborn Hematocrit cardiovascular system Gestation Female business Copper deficiency Copper |
| Zdroj: | Developmental Pharmacology and Therapeutics. 17:172-179 |
| ISSN: | 2504-2505 0379-8305 |
| Popis: | An experimental model using rats is described, in which a state of copper deficiency was produced in pregnant dams and their offspring. In 100% of the neonates from the copper-deficient group (10/10), 20% (2/10) from the control group, and 40% (4/10) from the pair-fed group, the ductus arteriosus was found to remain patent. These figures were highly significant in statistical terms (X2 test; p less than 0.0009). The possible physiopathology of the persistence of the ductus arteriosus in copper-deficient neonates is discussed. |
| Databáze: | OpenAIRE |
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