Association of the chromosome 11q13.5 variant with atopic dermatitis in Austrian patients
| Autor: | Andreas Gleiss, Friedrich Zimprich, Tamara Kopp, Alexander Zimprich, Elli K. Greisenegger |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Rhinitis Allergic Perennial Adolescent Genotype Population Genome-wide association study Single-nucleotide polymorphism Dermatology Immunoglobulin E Polymorphism Single Nucleotide Dermatitis Atopic Atopy Young Adult Intermediate Filament Proteins Polymorphism (computer science) medicine Humans education Child Genetic association Aged education.field_of_study biology business.industry Chromosomes Human Pair 11 Calcium-Binding Proteins Atopic dermatitis Middle Aged medicine.disease Asthma body regions Phenotype Austria Case-Control Studies Immunology biology.protein Female business |
| Zdroj: | European journal of dermatology : EJD. 23(2) |
| ISSN: | 1952-4013 |
| Popis: | Background: Recently, the two single nucleotide polymorphisms, rs7927894 on chromosome 11q13.5 and rs877776 within the region of the hornerin gene, were identified as novel susceptibility variants for atopic dermatitis in the first genome wide association study in atopic dermatitis. Objective: The aim of our study was to evaluate the influence of these two genetic variants on atopic dermatitis and disease-related phenotypes in the Austrian population. Methods: 275 atopic dermatitis patients and 243 controls were genotyped for the two variants rs7927894 and rs877776 by using Taqman based allelic discrimination assays. Results: When comparing patients with controls we found a significant association of the rs7927894 variant on chromosome 11q13.5 with atopic dermatitis (OR: 1.71; CI 1.14-2.59; p = 0.010). Subgroup analysis revealed no significant association of rs7927894 with early age of onset of the disease, concomitant asthma and allergic rhinoconjunctivitis, total serum IgE levels and family history of atopy. The analysis of the rs877776 variant showed neither a relevant difference in the allelic distribution between patients and controls nor a statistically significant association with any of the analyzed atopic dermatitis phenotypes. Conclusions: In summary our data show a statistically significant association of the rs7927894 variant on chromosome 11q13.5 with atopic dermatitis but not with other disease-related phenotypes. Therefore, we assume that the rs7927894 single nucleotide polymorphism selectively influences eczema development. More investigations in distinct study populations are needed to assess the role of this interesting polymorphism in atopic dermatitis. |
| Databáze: | OpenAIRE |
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