Molecular sieving by glomerular basement membrane

Autor:	Norman Kalant, Linda Hutton, Flora Y. Y. Huang
Rok vydání:	1967
Předmět:	Basement membrane Carbon Isotopes Multidisciplinary Nephrotic Syndrome Chemistry Glomerular basement membrane Kidney Glomerulus Basement Membrane Permeability Glomerular capillary Rats medicine.anatomical_structure medicine Biophysics Chromatography Gel Animals Serum Albumin Radio-Iodinated Mannose
Zdroj:	Nature. 216(5110)
ISSN:	0028-0836
Popis:	OF the three layers of the glomerular capillary wall—endothelial cells, basement membrane and epithelial cells—the basement membrane appears to be the only complete barrier between the plasma and the glomerular filtrate1,2. Support for the view that the basement membrane is the most important filtering mechanism was provided by the studies on ferritin transfer across the glomerular capillary wall2–5. Graham and Karnovsky6 have concluded that the epithelial slits are the primary filtration barrier and suggested that glomerular basement membrane acts only as a “coarse” filter. It is thus still not established whether the basement membrane acts as a filter.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fe46abe7adfbe9db2c310e1404be58 https://pubmed.ncbi.nlm.nih.gov/6050686 Zobrazit plný text záznamu