Comparison of prophylactic antibiotic regimens in patients undergoing vascular surgery
| Autor: | H.K. Litherland, J.A. Smith, J. Murphy, M. Walker |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty medicine.drug_class Premedication Antibiotics Cefazolin Placebo law.invention Veins Random Allocation Randomized controlled trial Blood vessel prosthesis law Medicine Humans Surgical Wound Infection Prospective Studies Retrospective Studies Cross Infection Dose-Response Relationship Drug business.industry General Medicine Vascular surgery Surgery Blood Vessel Prosthesis Clinical trial Infectious Diseases Anesthesia Drug Evaluation business Vascular Surgical Procedures medicine.drug |
| Zdroj: | The Journal of hospital infection. 5 |
| ISSN: | 0195-6701 |
| Popis: | An unacceptably high infection rate in patients undergoing vascular surgery prompted two studies on these patients. The first study confirmed the problem and described antibiotic usage which was not standardized. A second double blind randomized study compared antibiotic usage in two groups of patients, receiving vein grafts or synthetic grafts. Patients receiving vein grafts were randomized either to placebo or cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Patients receiving synthetic grafts were randomized either to cefazolin 1 g or to cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Four of 50 vein graft patients developed a purulent discharge. Two of these infected patients received placebo and two received the cefazolin 2 g protocol. Of 90 patients receiving a synthetic graft, four became infected. Three patients were randomized to the cefazolin 1 g protocol and one to the cefazolin 2 g protocol. No statistically significant differences were observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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