Risk factors for microangiopathy-related cerebral damage in the Austrian stroke prevention study
| Autor: | Marianne Hayn, Helena Schmidt, Gudrun Roob, Bernd Eber, Hermann Esterbauer, Reinhold Schmidt, Gerd M. Kostner, Hans Offenbacher, Martin Schumacher, Viktor Weinrauch, Peter Kapeller, Franz Fazekas |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Aging Apolipoprotein B Fibrinogen Gastroenterology Antioxidants Brain Ischemia Central nervous system disease Cohort Studies Apolipoproteins E Risk Factors Internal medicine medicine Humans Risk factor Aged Polymorphism Genetic biology business.industry Microcirculation Microangiopathy Odds ratio Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Cerebrovascular Disorders Blood pressure Logistic Models Neurology Antibodies Anticardiolipin biology.protein Female Neurology (clinical) business medicine.drug |
| Zdroj: | Journal of the neurological sciences. 152(1) |
| ISSN: | 0022-510X |
| Popis: | Microangiopathy-related cerebral damage (MARCD) represents a common incidental MRI observation in the elderly. The risk factors of such findings are widely unknown. We therefore performed MRI in 349 randomly selected volunteers (ages 50 to 70 years) without neuropsychiatric disease, and evaluated the association of MARCD with conventional and recently suggested cerebrovascular risk factors such as apolipoprotein E genotypes, plasma concentrations of essential antioxidants and anticardiolipin antibody titres. MARCD was defined as evidence of early confluent and confluent deep white matter hyperintensities and lacunes. It was present in 71 (20.3%) subjects. Individuals with MARCD were older than those without such findings (62.7 years vs 59.6 years; P=0.0001). They had a higher rate of arterial hypertension (45.1% vs 28.1%; P=0.006) and cardiac disease (50.7% vs 37.1%; P=0.04), higher systolic blood pressure readings at exam (144.4 mmHg vs 136.7 mmHg; P=0.004), and higher serum fibrinogen concentrations (327.1 mg/dl vs 292.5 mg/dl; P=0.001). Their levels of total cholesterol (217.6 mg/dl vs 231.2; P=0.009), apolipoprotein A-I (167.3 mg/dl vs 177.4 mg/dl, P=0.02), lycopene (0.17 micromol/l vs 0.24 micromol/l; P=0.003), retinol (1.91 micromol/l vs 2.10 micromol/l; P=0.02) and alpha-tocopherol (27.55 micromol/l vs 31.14 micromol/l; P=0.001) were significantly lower. Forward stepwise regression analysis created a model of independent predictors of MARCD with age entering first (odds ratio 2.01/10 years), fibrinogen second (odds ratio 2.45/100 mg/dl), alpha-tocopherol third (odds ratio 0.55/10 micromol/l), and arterial hypertension fourth (odds ratio 1.96). The association of MARCD with various treatable clinical conditions may have preventive implications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect