Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets
| Autor: | Nigulas Samel, V. Mardla, M. Lõhmus, Ivar Järving, Aino Vahemets, Ülo Lille, Gennadi Kobzar |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Platelet Aggregation medicine.medical_treatment Immunology Pharmacology medicine Potency Animals Humans Platelet Lagomorpha biology Chemistry Prostaglandins E Biological activity biology.organism_classification Epoprostenol Adenosine Diphosphate Eicosanoid Coagulation Biochemistry Platelet-rich plasma lipids (amino acids peptides and proteins) Female Rabbits Platelet Aggregation Inhibitors Prostaglandin E |
| Zdroj: | Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 106(2) |
| ISSN: | 0742-8413 |
| Popis: | 1. The anti-aggregatory potency of a number of E-type PGs was compared in human and rabbit platelet-rich plasma (PRP) and washed platelets. The potency of 13,14-dihydro-PGE 1 and 5,6-dihydro-PGE 3 is significantly higher in human than in rabbit washed platelets, while the potency of 15-keto-13,14-dihydro-PGE 1 is higher in rabbit. 2. The potency of PGEs in rabbit PRP is very similar to that of washed platelets, with the exception of 1a,1b-dihomo-PGE 2 , which is of a significantly lower potency in PRR. 3. In human, 5,6-trans-PGE 2 , PGE 3 , and 15-keto-13,14-dihydro-PGE 1 are more potent in PRP than in washed platelets. 4. The results indicate that the potency of E-type PGs in human and rabbit platelets is different and plasma can essentially influence the anti-aggregatory effect of PGEs; plasma can either decrease or increase potency. |
| Databáze: | OpenAIRE |
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