Greater aortic stiffness is associated with renal dysfunction in participants of the ELSA-Brasil cohort with and without hypertension and diabetes

Autor: José Geraldo Mill, Lidyane do Valle Camelo, Luisa Campos Caldeira Brant, Sandhi Maria Barreto, Paulo A. Lotufo, Júlia Sosa Antunes Cândido, Bruce Bartholow Duncan, Antonio Luiz Pinho Ribeiro
Rok vydání: 2019
Předmět:
Male
Physiology
Blood Pressure
030204 cardiovascular system & hematology
Vascular Medicine
Biochemistry
Stiffness
Cohort Studies
chemistry.chemical_compound
Diabetes mellitus
Endocrinology
0302 clinical medicine
Chronic Kidney Disease
Medicine and Health Sciences
Diabetes diagnosis and management
030212 general & internal medicine
Pulse wave velocity
Aorta
Multidisciplinary
Middle Aged
Nefropatias
Nephrology
Hypertension
Physical Sciences
Cardiology
Medicine
Female
Anatomy
Brazil
Glomerular Filtration Rate
Research Article
Adult
medicine.medical_specialty
HbA1c
Endocrine Disorders
Science
Materials Science
Material Properties
Renal function
Rigidez vascular
Diabetes Complications
03 medical and health sciences
Vascular Stiffness
Internal medicine
Diabetes Mellitus
medicine
Albuminuria
Humans
Mechanical Properties
Hemoglobin
Renal Insufficiency
Chronic

Aged
Renal Physiology
Creatinine
business.industry
Biology and Life Sciences
Proteins
Renal System
medicine.disease
Diagnostic medicine
Cross-Sectional Studies
Blood pressure
chemistry
Metabolic Disorders
Arterial stiffness
Glycated hemoglobin
business
Hipertensão
Kidney disease
Zdroj: PLoS ONE
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
PLoS ONE, Vol 14, Iss 2, p e0210522 (2019)
ISSN: 1932-6203
Popis: Background Arterial stiffness has been associated with renal dysfunction and its progression, but the pathophysiological relation underlying this association has not been fully established, particularly among individuals without hypertension and diabetes. We investigated the cross-sectional associations between arterial stiffness and renal function in adults without cardiovascular disease, and whether this association remained among subjects without hypertension and diabetes. Methods All eligible participants from ELSA-Brasil (2008–2010), aged 35 to 74 years (N = 13,586) were included, of whom 7,979 were free from hypertension and diabetes. The response variables were: 1) low glomerular filtration rate (eGFR
Databáze: OpenAIRE