| Autor: |
Paul G. Carty, Michael McCarthy, Sinéad M. O’Neill, Cillian F. De Gascun, Patricia Harrington, Michelle O’Neill, Susan M. Smith, Conor Teljeur, Mairin Ryan |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Reviews in medical virologyREFERENCES. 32(4) |
| ISSN: |
1099-1654 |
| Popis: |
The use of dried blood spot (DBS) samples can facilitate the implementation of reflex testing by circumventing the need for centrifugation and freezing of venous blood samples. This systematic review assessed the accuracy of using DBS samples to diagnose chronic hepatitis C virus (HCV) infection. A comprehensive search was undertaken to identify articles published up to July 2020 evaluating the diagnostic accuracy of anti-HCV, HCV-RNA and HCV core antigen tests using DBS. Screening, data extraction, quality appraisal and Grading of Recommendations, Assessment, Development and Evaluations certainty of the evidence assessment were performed independently by two reviewers. Meta-analysis, meta-regression and sensitivity analyses were conducted. The evidence demonstrates that laboratory-based anti-HCV and HCV-RNA tests using DBS samples have high diagnostic accuracy. All comparisons were between DBS and venous samples. For the detection of anti-HCV, sensitivity was 95% (95% CI: 92%-97%) and specificity was 99% ([95% CI: 98%-99%]; n = 25; I |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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