Irritant Patch Testing: Penetration of Sodium Lauryl Sulphate into Human Skin
| Autor: | Ann Fullerton, Urs Broby-Johansen, Tove Agner, Walther Batsberg |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Skin Absorption Human skin Dermatology Patch testing In vivo medicine Humans Skin Skin Tests Pharmacology Aqueous solution Chromatography integumentary system Chemistry Sodium lauryl sulphate Sodium Dodecyl Sulfate Water Patch test General Medicine Penetration (firestop) Middle Aged Permeation Solutions Female Pharmaceutical Vehicles Gels |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1660-5535 1660-5527 |
| Popis: | To clarify the sources of variation in irritant patch testing, variability in delivery of the test substance from the patch test system was studied. An in vitro model was used to study the penetration of sodium lauryl sulphate (SLS) from a patch test system into the skin. Different formulations of SLS applied to the skin for 24 h were studied (aqueous solution and gels), but irrespective of the vehicle used permeation of SLS into the recipient phase was poor. Results were compared to in vivo patch testing in 12 subjects. Approximately 70% of the applied SLS in aqueous soltion was released from the patch test system. Release from gels was poorer. High concordance between the in vivo and the in vitro model was found. No correlation was found between the amount of SLS left in the filter disc and the strentgh of the clinical reaction in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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