Ambulatory monitoring of systolic hypertension in the elderly: Eprosartan/hydrochlorothiazide compared with losartan/hydrochlorothiazide (INSIST trial)

Autor: Bruno Trimarco, Giuseppe Palasciano, Cristiana Leprotti, Giuseppe Mulè, Francesco Cipollone, Antonio Salvetti, Gabriella Melzi, Ettore Ambrosioni, Claudio Ferri, Michele Bombelli, Giuseppe Mancia, Irene Grazioli, Amedeo Mugellini, Giovanni Cerasola
Přispěvatelé: Ambrosioni, E, Bombelli, M, Cerasola, G, Cipollone, F, Ferri, C, Grazioli, I, Leprotti, C, Mancia, G, Melzi, G, Mugellini, A, Mulè, G, Palasciano, G, Salvetti, A, Trimarco, B, Ferri, C, Grazioli, I, Trimarco, Bruno
Rok vydání: 2010
Předmět:
Male
Systolic hypertension
Office Visits
Pharmacology
Severity of Illness Index
law.invention
Hydrochlorothiazide
Randomized controlled trial
law
Angiotensin II Type 1 Receptor Blocker
Pharmacology (medical)
Diuretics
Imidazoles
General Medicine
Blood Pressure Monitoring
Ambulatory
Antihypertensive Agent
Losartan
Treatment Outcome
Acrylates
Hypertension
Cardiology
Drug Therapy
Combination
Female
Drug Monitoring
Human
medicine.drug
medicine.medical_specialty
Ambulatory blood pressure
Systole
Losartan/hydrochlorothiazide
Thiophenes
elderly patients
elderly
Statistics
Nonparametric
Double-Blind Method
Thiophene
Internal medicine
medicine
Diuretic
Humans
Imidazole
Antihypertensive Agents
Aged
Analysis of Variance
business.industry
eprosartan
Eprosartan
medicine.disease
ambulatory blood pressure monitoring
Acrylate
Blood pressure
Office Visit
business
Angiotensin II Type 1 Receptor Blockers
Zdroj: Advances in therapy. 27(6)
ISSN: 1865-8652
Popis: Introduction: Systolic hypertension is very common in the elderly and is strongly associated with the risk of cardiovascular and cerebrovascular events. The control of systolic hypertension is difficult and most patients require combination antihypertensive therapy. Few data are available regarding the efficacy of angiotensin II receptor antagonists on systolic hypertension of the elderly. The aim of this double-blind, double-dummy, randomized, parallel-group, multicenter study was to assess the efficacy of eprosartan 600 mg in combination with hydrochlorothiazide (HCTZ)12.5 mg in comparison with losartan 50 mg in combination with HCTZ 12.5 mg, in reducing blood pressure in elderly patients with grade 2 systolic hypertension who did not optimally respond to eprosartan or losartan monotherapy. Methods: After a 3-week placebo wash-out, 155 patients with an Office trough sitting systolic blood pressure (Office sitSBP) ≥160 mmHg and
Databáze: OpenAIRE
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