AA amyloidosis associated with systemic lupus erythematosus: impact on clinical course and outcome
| Autor: | Nurşen Düzgün, Sehsuvar Erturk, Arzu Ensari, Müyesser Sayki, Banu Yilmaz, Levent Yazicioglu, Türkan Mete |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Nephrotic Syndrome medicine.medical_treatment Multiple Organ Failure Immunology Heart Rupture Fatal Outcome Rheumatology AA amyloidosis Internal medicine Mitral valve Immunology and Allergy Medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Heart Failure Heart Valve Prosthesis Implantation Mitral regurgitation Lupus erythematosus business.industry Amyloidosis Mitral valve replacement Mitral Valve Insufficiency Acute Kidney Injury Middle Aged medicine.disease Shock Septic medicine.anatomical_structure Cardiology Chordae Tendineae Female Chordae tendineae business Nephrotic syndrome |
| Zdroj: | Rheumatology international. 28(4) |
| ISSN: | 0172-8172 |
| Popis: | Secondary amyloidosis (AA amyloidosis) has rarely been described in patients with systemic lupus erythematosus (SLE). We, herein, present a 56-year-old female patient, who developed AA amyloidosis following a 22-year history of SLE. She developed severe mitral regurgitation complicated with chordae tendinea rupture that led to acute congestive heart failure and went on a mitral valve replacement, where no flare symptoms of SLE were present. Three months after the operation, she presented with a nephrotic-range proteinuria, acute renal failure, and severe sepsis. She was found to have new vegetations on replaced valve and multi-organ failure caused her death. Re-evaluation of the excised mitral valve revealed AA amyloid deposition. Post-mortem biopsies from the kidney and bone marrow also revealed secondary amyloidosis. |
| Databáze: | OpenAIRE |
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