Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria

Autor: Fabio T. M. Costa, Selma Giorgio, Alessandro S. Farias, Rogerio Amino, Yara C. Blanco, Stefanie C. P. Lopes, Leonilda M.B. Santos, Bruna O. Carvalho, Uta Goelnitz, Gerhard Wunderlich, Wagner Welber Arrais-Silva
Jazyk: angličtina
Rok vydání: 2008
Předmět:
medicine.medical_specialty
Plasmodium berghei
medicine.medical_treatment
T-Lymphocytes
Malaria
Cerebral
lcsh:Medicine
Parasitemia
Gastroenterology
Mice
Internal medicine
Oxygen therapy
parasitic diseases
medicine
Animals
lcsh:Science
Stroke
Neurological Disorders/Infectious Diseases of the Nervous System
Coma
Hyperbaric Oxygenation
Multidisciplinary
biology
business.industry
lcsh:R
Infectious Diseases/Protozoal Infections
Temperature
Neurological Disorders/Cerebrovascular Disease
Brain
Hypothermia
biology.organism_classification
medicine.disease
Surgery
Mice
Inbred C57BL
Oxygen
Disease Models
Animal
Treatment Outcome
Migraine
Infectious Diseases/Neglected Tropical Diseases
Gene Expression Regulation
Cerebral Malaria
Pathology/Neuropathology
lcsh:Q
medicine.symptom
business
Pathology/Hematology
Research Article
Infectious Diseases/Tropical and Travel-Associated Diseases
Zdroj: PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3126 (2008)
ISSN: 1932-6203
Popis: BACKGROUND: Cerebral malaria (CM) is a syndrome characterized by neurological signs, seizures and coma. Despite the fact that CM presents similarities with cerebral stroke, few studies have focused on new supportive therapies for the disease. Hyperbaric oxygen (HBO) therapy has been successfully used in patients with numerous brain disorders such as stroke, migraine and atherosclerosis. METHODOLOGY/PRINCIPAL FINDINGS: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) were exposed to daily doses of HBO (100% O(2), 3.0 ATA, 1-2 h per day) in conditions well-tolerated by humans and animals, before or after parasite establishment. Cumulative survival analyses demonstrated that HBO therapy protected 50% of PbA-infected mice and delayed CM-specific neurological signs when administrated after patent parasitemia. Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gammadelta and alphabeta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB) dysfunction and hypothermia. CONCLUSIONS/SIGNIFICANCE: The data presented here is the first indication that HBO treatment could be used as supportive therapy, perhaps in association with neuroprotective drugs, to prevent CM clinical outcomes, including death.
Databáze: OpenAIRE
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