Prognostic factors associated with improved outcome ofEscherichia coli bacteremia in a Finnish university hospital
| Autor: | Aulikki Sivonen, Arja Kuikka, Ville Valtonen, A. Emelianova |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pediatrics Antibiotics Bacteremia Logistic regression Hospitals University 0302 clinical medicine Medical microbiology 030212 general & internal medicine Child Escherichia coli Infections Finland Cross Infection 0303 health sciences General Medicine Analgesics Non-Narcotic Middle Aged Prognosis Anti-Bacterial Agents 3. Good health Treatment Outcome Infectious Diseases Child Preschool Shock (circulatory) Regression Analysis Drug Therapy Combination Female medicine.symptom medicine.drug Adult Microbiology (medical) medicine.medical_specialty Adolescent medicine.drug_class 03 medical and health sciences Internal medicine medicine Humans Risk factor Acetaminophen Aged Retrospective Studies 030306 microbiology business.industry Infant Newborn Infant medicine.disease Pneumonia business |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 16:125-134 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/bf01709471 |
| Popis: | All cases of bacteremia caused solely by Escherichia coli in 1977-1979, 1987-1989, and 1993-1994 in a Finnish university hospital were reviewed retrospectively to determine the clinical manifestations, the outcome, and the prognostic factors. In 332 episodes, mortality during the month after the first positive blood culture was 17%. This figure diminished during the study period from 23% in the 1970s to 9% in the 1990s (p = 0.028). Mortality was lowest among patients treated with a combination of antibiotics, 7% versus 18% among those treated otherwise (p = 0.034). The use of acetaminophen increased during the study period from 18 to 55%. Mortality among patients who received acetaminophen within a period24 h to 48 h of the first positive blood culture was 10% versus 22% among others (p = 0.002). Logistic regression analysis showed six factors predictive of a fatal outcome: pneumonia, no known focus, shock, CNS disorder, thromboembolism, and rapidly fatal underlying disease. Appropriate antibiotic therapy predicted survival. In the analysis, replacement of appropriate antibiotic therapy by acetaminophen revealed that this drug was significantly associated with survival. |
| Databáze: | OpenAIRE |
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