Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain
| Autor: | Sanja Pekovic, Sanja Subasic, Irena Lavrnja, Ljubisav Rakic, Nadezda Nedeljkovic, Ivana Bjelobaba, Danijela Stojkov, Mirjana Stojiljkovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Ependymal Cell Thalamus Central nervous system Blotting Western Hippocampus Biology 03 medical and health sciences 0302 clinical medicine Prosencephalon Internal medicine medicine Animals Pyrophosphatases Rats Wistar Molecular Biology 030304 developmental biology 0303 health sciences Phosphoric Diester Hydrolases General Neuroscience Immunohistochemistry Cell biology Rats medicine.anatomical_structure Endocrinology nervous system Cerebral cortex Forebrain Choroid plexus Neurology (clinical) Pyramidal cell 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research |
| Popis: | Immunohistochemical study was performed to determine distribution of ecto-nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) in adult rat forebrain. The study revealed widespread distribution of NPP1 in rat forebrain, yet with regional differences in the expression pattern and abundance. Strong NPP1 immunoreaction was detected in pyramidal cell layer of cerebral cortex and hippocampus, and in the midline regions of hypothalamus and thalamus. In many immunopositive forebrain areas, NPP1 was mainly localized at neuronal cell bodies. However, prominent immunoreaction was also detected at ependymal cells, tanycytes, endothelial cells of the capillaries and cells of the choroid plexus, suggesting that NPP1 could be involved in some highly specialized transport process. (c) 2006 Elsevier B.V. All rights reserved. null |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|