Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma
| Autor: | Thomas Bengtsson, Mette N. Hermansen, Jakob Jessing Jespersen, Frederik Buchvald, Kim G. Nielsen, Hans Bisgaard |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Adolescent medicine.drug_class Bronchoconstriction Terbutaline Critical Care and Intensive Care Medicine Double-Blind Method Forced Expiratory Volume Formoterol Fumarate Bronchodilator Administration Inhalation medicine Humans Child Asthma Cross-Over Studies Dose-Response Relationship Drug business.industry Adrenergic beta-Agonists medicine.disease Dry-powder inhaler respiratory tract diseases Treatment Outcome Ethanolamines Delayed-Action Preparations Anesthesia Exhaled nitric oxide Exercise Test Female Formoterol medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies medicine.drug |
| Zdroj: | Chest. 129:1203-1209 |
| ISSN: | 0012-3692 |
| Popis: | Study objective To compare the acute bronchodilatory effect of the long-acting β 2 -agonist formoterol against the short-acting β 2 -agonist (SABA) terbutaline during exercise-induced bronchoconstriction (EIB) in children with asthma. Design A randomized, double-blind, placebo-controlled, crossover study of the immediate effect of formoterol, 9 μg, vs terbutaline, 0.5 mg, and placebo administered as dry powder at different study days. Exercise challenge test was used as a model of acute bronchoconstriction. Patients Twenty-four 7- to 15-year-old children with persistent asthma. Interventions The children performed standardized treadmill exercise tests, breathing dry air, with a submaximal workload. Study medication was administered 5 min after exercise if FEV 1 dropped ≥ 15% within 5 min after exercise. FEV 1 and forced expiratory flows were measured repeatedly until 60 min after dose. Results Formoterol and terbutaline offered a significant acute bronchodilatory effect from 3 min after dose compared with placebo (p 1 5 min after dose (p = 0.15), with a mean increase from each predrug baseline of 62% of the maximum increase for both. Median times to recovery within 5% of baseline FEV 1 were 5.0 min and 7.4 min for formoterol and terbutaline, respectively (p = 0.33). Conclusion Single-dose formoterol, 9 μg, via dry powder inhaler provided an acute bronchodilatory effect similar to terbutaline during EIB in schoolchildren with persistent asthma. Formoterol is at least as effective as SABA and may be considered an alternative in the treatment of acute bronchoconstriction in school children. |
| Databáze: | OpenAIRE |
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