Nationwide Seropositivity of Hepatitis A in Republic of Korea from 2005 to 2014, before and after the Outbreak Peak in 2009

Autor: Anna Lee, Kyung-Ah Kim, Moran Ki, Sook Hyang Jeong
Rok vydání: 2017
Předmět:
Male
Gastroenterology and hepatology
viruses
lcsh:Medicine
Hepatitis A Antibodies
Geographical locations
Disease Outbreaks
Hepatitis
0302 clinical medicine
Seroepidemiologic Studies
Public and Occupational Health
030212 general & internal medicine
lcsh:Science
Child
Pathology and laboratory medicine
Geographic Areas
Multidisciplinary
Geography
virus diseases
Hepatitis A
Middle Aged
Medical microbiology
Vaccination and Immunization
Infectious hepatitis
Serology
Cohort effect
Child
Preschool
Viruses
Infectious diseases
Population study
Female
030211 gastroenterology & hepatology
Pathogens
Research Article
Adult
Asia
Adolescent
Immunology
Viral diseases
Microbiology
Young Adult
03 medical and health sciences
South Korea
Republic of Korea
medicine
Humans
Seroprevalence
Liver diseases
Retrospective Studies
Demography
Medicine and health sciences
Standard Population
Biology and life sciences
business.industry
lcsh:R
Infant
Newborn
Viral pathogens
Organisms
Immunity
Infant
Outbreak
Retrospective cohort study
medicine.disease
Hepatitis viruses
Rural Areas
Microbial pathogens
Earth Sciences
lcsh:Q
Hepatitis A virus
Preventive Medicine
People and places
business
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170432 (2017)
ISSN: 1932-6203
Popis: Background/Aims The epidemiologic shift of hepatitis A virus (HAV) infection in the South Korean population resulted in a peak outbreak of hepatitis in 2009. The aim of this study was to clarify the seropositivity of anti-HAV antibody (anti-HAV) and its demographic characteristics before and after the peak outbreak from 2005 to 2014. Methods This retrospective study analyzed the anti-HAV data of all individuals from 1,795 medical institutions referred to a major central laboratory from January 2005 through December 2014, as a sentineal tool for monitoring annual variation of anti-HAV positivity. The prevalence of anti-HAV was adjusted for age and area with the standard population based on the 2010 Census data. Results A total of 424,245 individuals were included in this study. The overall age-adjusted anti-HAV prevalence decreased from 65.6% in 2005 to 62.2% in 2014. During the 10-year period, the seroprevalence continuously decreased in persons aged 30 to 39 years (69.6% to 32.4%) and those aged 40 to 49 years (97.9% to 79.3%) due to the cohort effect. In contrast, it increased in persons aged 10 to 19 years (15.4% to 35.2%), while it was the lowest (8.7%) in 2010 before rebounding to 20.2% in 2014 in persons aged 20 to 29 years due to a vaccination effect. Conclusion Although the HAV vaccination rate increased, the anti-HAV seropositivity in South Korea decreased from 65.6% to 62.2% in this study population. In particular, the immunity of young adults was still low, and an outbreak of HAV is possible in the near future. Therefore, continuous monitoring and optimal preventive measures to prevent future outbreaks should be considered.
Databáze: OpenAIRE
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