Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
| Autor: | Christian Niel, Alexandro Guterres, Neusa Araújo, Lima Lrp, José Henrique Pilotto, Paula Vs |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) lcsh:Arctic medicine. Tropical medicine Genes Viral lcsh:RC955-962 Herpesvirus 2 Human Short Communication viruses lcsh:QR1-502 HIV Infections Biology Polymerase Chain Reaction lcsh:Microbiology DNA sequencing law.invention 03 medical and health sciences co-infection law Genotype Genetic variation medicine Humans Genetic variability glycoprotein B Gene Polymerase chain reaction Phylogeny Genetics Genetic diversity Herpes Genitalis clade Coinfection virus diseases HIV biochemical phenomena metabolism and nutrition medicine.disease HSV-2 030104 developmental biology HIV-1 Female Brazil |
| Zdroj: | Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 12, Article number: e180328, Published: 03 DEC 2018 Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 12 (2018) |
| Popis: | BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated. |
| Databáze: | OpenAIRE |
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