Metabolic tumor volume and total lesion glycolysis as prognostic factors in head and neck cancer: Systematic review and meta-analysis
| Autor: | Jesús Romero, Ana Royuela, S. Marcos, Jefferson Rijo-Cedeño, Jorge Mucientes, O. Álvarez, José Ramón García-Berrocal |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Internal medicine Positron Emission Tomography Computed Tomography Overall survival Medicine Humans Retrospective Studies business.industry Head and neck cancer Hazard ratio Cancer Metabolic tumor volume medicine.disease Prognosis Tumor Burden Clinical Practice Total lesion glycolysis Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Meta-analysis Positron-Emission Tomography Radiopharmaceuticals business Glycolysis |
| Zdroj: | HeadneckREFERENCES. 42(12) |
| ISSN: | 1097-0347 |
| Popis: | The role of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in head and neck cancer (HNC) prognosis is not well established. We conducted a systematic review focusing on MTV and TLG measured by 18 F-FDG positron-emission tomography in HNC. Meta-analyses were developed, estimating hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS). Eighteen studies were found with a total of 1512 patients. MTV-adjusted analysis had an HR of 4.65 (95% CI = 2.04-10.6) for DFS and 3.89 (95% CI = 1.47-10.30) for OS. TLG-unadjusted analysis had an HR of 3.19 (95% CI = 2.33-4.37) for DFS and 2.48 (95% CI = 1.82-3.39) for OS. TLG-adjusted analysis for DFS obtained an HR of 2.05 (95% CI = 0.96-4.39). MTV and TLG are good prognostic factors in HNC, as high values predict a worse OS and DFS. Given the important information they provide, these parameters may be considered in clinical practice, as they are easily obtainable with current technology. |
| Databáze: | OpenAIRE |
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