Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

Autor:	Malbert R. C. Rogers, Ad C. Fluit, Marrie C A Bruin, Rob J. Rentenaar, Annelies M. C. Mavinkurve-Groothuis, Tim T Severs, Tom F.W. Wolfs, Miquel B. Ekkelenkamp
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male meropenem resistant Bacteremia medicine.disease_cause Pediatrics sepsis Fatal Outcome 0302 clinical medicine polycyclic compounds Blood culture 030212 general & internal medicine imipenem resistant Sequence Deletion medicine.diagnostic_test Perinatology Anti-Bacterial Agents and Child Health Infectious Diseases Porin Pseudomonas aeruginosa oprD Bacterial outer membrane medicine.drug Microbiology (medical) Adolescent Porins Meropenem beta-Lactam Resistance Microbiology Sepsis 03 medical and health sciences 030225 pediatrics medicine Journal Article Humans Pseudomonas Infections Pediatrics Perinatology and Child Health Whole Genome Sequencing business.industry biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease febrile neutropenia Blood Culture Mutation Pediatrics Perinatology and Child Health business Febrile neutropenia mexR
Zdroj:	The Pediatric infectious disease journal, 38(4), 398. Lippincott Williams and Wilkins
ISSN:	0891-3668
Popis:	A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8edfc6bfc6fec4fdc32857345a9ca88 https://dspace.library.uu.nl/handle/1874/391951 Zobrazit plný text záznamu