Nasal Inflammation and Ulceration Secondary to Repeated Use of an Intranasal Delivery Device in Rabbits
| Autor: | Yuval Ramot, Ruth Goldschmidt, Abraham Nyska, Dalia Shabashov Stone |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
040301 veterinary sciences
Nose Toxicology Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Animal model Medicine Animals Humans skin and connective tissue diseases Molecular Biology Administration Intranasal Ulcer Inflammation business.industry 04 agricultural and veterinary sciences Cell Biology Pharmaceutical Preparations Anesthesia Nasal inflammation Nasal administration sense organs Rabbits business 030217 neurology & neurosurgery |
| Zdroj: | Toxicologic pathology. 48(7) |
| ISSN: | 1533-1601 |
| Popis: | Intranasal administration of drugs is gaining popularity in medicine, and several animal models have been used to test the safety and efficacy of this delivery route. Nevertheless, the nasal anatomy of animals is different from humans, which can lead to pathological changes that stem from the delivery device and not the drug itself. Here, we report on nasal inflammation and ulceration in rabbits, secondary to the repeated trauma caused by the intranasal device. Similar changes were noted in the animals treated with the vehicle and with the tested drug, and therefore, these changes were not attributed to the drug itself. In some animals, superficial ulcer and stromal inflammation were noted in the eyes, secondary to nasal duct obstruction from the nasal inflammation. These observations emphasize the importance of proper interpretation of histopathological changes, attributed to trauma-induced pathological changes related to the handling of the animal and not to the tested product, which is the drug itself and the device that is optimized for clinical (human) use. |
| Databáze: | OpenAIRE |
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