Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi
| Autor: | Christopher P. Gordon, Mark J. Robertson, Adam McCluskey, Jana Guenther, Anthony D. Wright, Kylie A. MacGregor |
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| Rok vydání: | 2010 |
| Předmět: |
Models
Molecular Stereochemistry Biofouling Photosynthesis Sesquiterpene Biochemistry chemistry.chemical_compound Hemoglobins Axinella Anti-Infective Agents Nitriles Bioassay Animals Humans Acanthella Physical and Theoretical Chemistry Cymbastela biology Molecular Structure Organic Chemistry Active site biology.organism_classification Sponge chemistry biology.protein Diterpene Diterpenes |
| Zdroj: | Organicbiomolecular chemistry. 9(2) |
| ISSN: | 1477-0539 |
| Popis: | In an investigation into their potential ecological role(s), a group of mainly diterpene isonitriles, nine in total, isolated from the tropical marine sponge Cymbastela hooperi, and the sesquiterpene axisonitrile-3, isolated from the tropical marine sponge Acanthella kletra, were evaluated in a series of bioassays including anti-fouling, anti-algal, anti-photosynthetic, anti-bacterial (Gram +ve and −ve), anti-fungal, and anti-tubercular. The results of these assays showed that all of the tested compounds, with the exception of diterpene 9, were active in at least two of the applied test systems, with axisonitrile-3 (10) and diterpene isonitrile 1 being the two most active compounds overall, closely followed by diterpene isonitrile 3. Based on the results of the photosynthetic study a molecular modelling investigation was undertaken with all of the compounds used in that study. The results showed a positive correlation between reduction in photosynthetic activity and the interaction of the modelled compounds with a potential enzyme active site. |
| Databáze: | OpenAIRE |
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