Lowering dietary phosphorus concentrations reduces kidney calcification, but does not adversely affect growth, mineral metabolism, and bone development in growing rabbits
| Autor: | A. C. Beynen, J. Ritskes-Hoitinga, H.N.A. Grooten, M.J.T.M. Peters, K. J. H. Wienk, A. G. Lemmens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Bone density Medicine (miscellaneous) chemistry.chemical_element restriction Growth Urine Biology Calcium Bone and Bones Excretion Internal medicine medicine Animals Minerals Kidney Bone Development Nutrition and Dietetics calcium induced nephrocalcinosis medicine.disease Unifarm female rats Diet Calcium Dietary Nephrocalcinosis Endocrinology medicine.anatomical_structure chemistry Phosphorus Dietary Rabbits Mineral balance Calcification |
| Zdroj: | Ritskes-Hoitinga, J, Grooten, H N, Wienk, K J, Peters, M, Lemmens, A G & Beynen, A C 2004, ' Lowering dietary phosphorus concentrations reduces kidney calcification, but does not adversely affect growth, mineral metabolism, and bone development in growing rabbits ', British Journal of Nutrition, vol. 91, no. 3, pp. 367-376 . British Journal of Nutrition 91 (2004) 3 British Journal of Nutrition, 91(3), 367-376 |
| ISSN: | 0007-1145 |
| Popis: | New Zealand White rabbits were used to investigate the influence of increasing dietary P concentrations on growth performance, mineral balance, kidney calcification and bone development. The minimum dietary P requirement of 0·22% (National Research Council) is usually exceeded in commercial natural-ingredient chows, leading to undesirable kidney calcifications. In order to study the optimal dietary P level, rabbits were fed semi-purified diets with four different P levels (0·1, 0·2, 0·4, and 0·8%; w/w) at a constant dietary Ca concentration (0·5%) during an 8-week period. Body weight and growth were not influenced by the dietary P level. During two periods (days 20–23 and 48–51), faeces and urine were collected quantitatively for the analysis of Ca, Mg and P and balances were calculated. Increased dietary P intake caused increased urinary and faecal P excretion and P apparent absorption and retention. Faecal Ca excretion increased with higher dietary P levels, whereas urinary Ca excretion reacted inversely. The apparent absorption of Ca became reduced at higher dietary P concentrations, but Ca retention was unchanged. The response of Mg was in a similar direction to that of the Ca balance. Kidney mineral content increased with higher dietary P levels, indicating the presence of calcified deposits. Nephrocalcinosis became more severe in kidney cortex and medulla at increasing dietary P levels, as was confirmed by histological analysis. Femur bone length was not differentially influenced by dietary P. Bone density (g/cm3) of the femur diaphysis became significantly lower at the 0·8% dietary P level as compared with the 0·2% P group only. The bone Mg content was significantly increased on the 0·8% P diet, both in the diaphysis and epiphysis. Plasma P concentration increased and plasma Ca decreased with higher dietary P levels, whereas plasma Mg levels were unaffected. The present study shows that the current recommended minimum dietary P level of 0·2% for rabbits, as advised by the National Research Council in 1977, leads to a normal growth and bone development, but also causes some degree of kidney calcifications at a dietary Ca level of 0·5%. As the dietary P level of 0·1% virtually prevented kidney calcification and at the same time did not give evidence for any deleterious effects on growth and bone development, this indicates that the current recommended dietary P level for rabbits should be regarded as a maximum advisable concentration, and that a lower P level may be more optimal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|