Comparative distribution of urocortin- and CRF-like immunoreactivities in the nervous system of the earthworm Lumbricus terrestris
| Autor: | Márta Szelier, Andrea Lubics, Dora Reglodi, Tamas Kozicz, István Lengvári |
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| Rok vydání: | 2003 |
| Předmět: |
Nervous system
Central Nervous System endocrine system medicine.medical_specialty Physiology Corticotropin-Releasing Hormone Central nervous system Neuropeptide Fluorescent Antibody Technique Biochemistry Cellular and Molecular Neuroscience Endocrinology Internal medicine Peripheral Nervous System otorhinolaryngologic diseases medicine Animals Oligochaeta Urocortins Urocortin Neurons Annelid biology biology.organism_classification Immunohistochemistry medicine.anatomical_structure Ventral nerve cord Ganglia hormones hormone substitutes and hormone antagonists Lumbricus terrestris |
| Zdroj: | Peptides. 24(2) |
| ISSN: | 0196-9781 |
| Popis: | Corticotropin-releasing factor (CRF) and urocortin (Ucn) are both members of the CRF neuropeptide family. The distribution of Ucn- and CRF-like immunoreactive (ir) structures in the central nervous system of several vertebrate species has been studied, but little is known about that in non-vertebrates. We used a highly specific polyclonal antibody against rat Ucn and CRF to determine and compare the distribution of Ucn- and CRF-like immunoreactivity in the earthworm nervous system. Several Ucn- and CRF-like ir perikarya were described in the cerebral ganglion, subesophageal and ventral cord ganglia. The majority of Ucn-like ir cells were found in the ventral ganglia, whereas CRF-like ir cells were most abundant in the cerebral ganglion. Scattered Ucn- and CRF-like ir varicose fiber terminals were seen in all areas of the earthworm central nervous system. Ucn-like ir cell bodies and fiber terminals were also demonstrated in the pharyngeal wall. No co-localization of Ucn- and CRF-like ir nervous structures were observed. This study provided morphological evidence that Ucn- and CRF-like neurosecretory products exist in the earthworm central nervous system. Furthermore, both the distribution and morphology of Ucn- and CRF-like ir structures were distinct, therefore, it can be hypothesized that these neuropeptides exert different neurendocrine functions in the earthworm nervous system. |
| Databáze: | OpenAIRE |
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