Clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 infection at Toulouse University hospital (France). Results from the Covid-clinic-Toul cohort
| Autor: | A. Jourdes, Stein Silva, C. Thalamas, Sandrine Charpentier, Vincent Minville, Margaux Lafaurie, G. Moulis, Agnès Sommet, M. Faruch, Pierre Delobel, Guillaume Martin-Blondel |
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| Přispěvatelé: | CCSD, Accord Elsevier, Service Maladies infectieuses et tropicales [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse] |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Epidemiology medicine.medical_treatment 030204 cardiovascular system & hematology COVID-2019 law.invention Cohort Studies Hospitals University 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Interquartile range law Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Aged Mechanical ventilation SARS-CoV-2 business.industry Gastroenterology COVID-19 Middle Aged medicine.disease Intensive care unit Comorbidity 3. Good health Épidémiologie Hospitalization Pneumonia Treatment Outcome Cohort [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Original Article Female France business Cohort study |
| Zdroj: | La Revue de Médecine Interne La Revue De Medecine Interne La Revue de Médecine Interne, 2020, 41 (11), pp.732-740. ⟨10.1016/j.revmed.2020.08.006⟩ |
| ISSN: | 0248-8663 1768-3122 |
| Popis: | Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide from epicenter of Wuhan, China since December 2019. The aim of our study was to describe the clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 pneumonia at the Toulouse university hospital, France. Patients and methods We selected the patients included from March 7, 2020 to April 20, 2020 in the retrolective Covid-clinic-Toul cohort that follows all hospitalized patients with SARS-CoV-2 infection at the Toulouse Hospital. Cases were confirmed by real-time reverse transcriptase polymerase chain reaction. We report demographics, clinical, biological and radiological features, as well as unfavorable outcome at Day 14 after admission (admission in an intensive care unit, mechanical ventilation, death). Results Among 263 hospitalized patients, the median age was 65 years and 155 (58.9%) were males. Two hundred and twenty-seven patients (86.3%) had at least one comorbidity. The median time from first symptom to hospital admission was 7.0 days (interquartile range: 4–10). On day 14 after admission, 111 patients (42.2%) had been transferred to intensive care unit (ICU), including 50 (19.0%) on Day 1; 61 (23.1%) needed mechanical ventilation and 19 patients (7.2%) had died. Patients admitted to ICU at Day 1 of admission (n = 50) were more frequently men (66.0% vs 57.3%), smokers (25.0% vs 7.1%), with obesity (42.0% vs 24.7%) and had a higher mean level of C-reactive protein (median: 110.9 mg/L vs 46.2 mg/L). Conclusion This cohort provides epidemiological data on SARS-CoV-2 in hospitalized patients in a University hospital in the South of France. |
| Databáze: | OpenAIRE |
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