Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment
| Autor: | Artemis Khatcherian, James G. Krueger, Irma Cardinale, Judilyn Fuentes-Duculan, Kamruz Darabi, John A. Carucci, Julia Whynot-Ertelt, Inna Novitskaya, Emma Guttman-Yassky, Michelle A. Lowes, Helen G. Kaporis, Asifa Haider |
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| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
Skin Neoplasms Biopsy Interferon Regulatory Factor-7 chemical and pharmacologic phenomena Dermatology Biology CD8-Positive T-Lymphocytes Biochemistry T-Lymphocytes Regulatory Immune system Th2 Cells Interferon medicine Humans IL-2 receptor Molecular Biology Tumor microenvironment integumentary system FOXP3 Forkhead Transcription Factors Cell Biology Dendritic Cells Interleukin-12 Interleukin-10 IRF1 Carcinoma Basal Cell Immunology Cancer research Interleukin 12 Interleukin-4 CD8 medicine.drug Interferon Regulatory Factor-1 |
| Zdroj: | The Journal of investigative dermatology. 127(10) |
| ISSN: | 1523-1747 |
| Popis: | Basal cell carcinoma (BCC), the most common human cancer, undergoes spontaneous regression in certain circumstances, which is potentially immune-mediated. To understand the immune response surrounding BCCs, we characterized the genomic, protein, and cellular microenvironment associated with BCC in comparison to normal skin. Our results demonstrated the following: (1) CD4 + CD25 + Foxp3 + surround epithelial tumor aggregates; (2) Immature dendritic cells (DCs) were abundant in the tumor microenvironment; (3) BCC showed increased expression of IL-4, IL-10, and CCL22 and increased expression of interferon-associated genes (IFI27, IRF1, IRF7, and G1P2) and IL-12/23, gene indicating a Th2 dominant microenvironment. Our findings suggest a dynamic state within the immune microenvironment associated with BCC. The finding of phenotypic T regs, in conjunction with immature DCs and Th2 cytokines, suggests an attenuated state of immunity to human BCC. In contrast, abundant CD8 + T cells, an interferon signal, and IL-12/23 suggest partial host antitumor response. A better understanding of these opposing forces within the immune microenvironment may facilitate development of more potent immune-based treatment for BCC and other human carcinomas. |
| Databáze: | OpenAIRE |
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